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  1. Research

    YY-1224, a terpene trilactone-strengthened Ginkgo biloba, attenuates neurodegenerative changes induced by β-amyloid (1-42) or double transgenic overexpression of APP and PS1 via inhibition of cyclooxygenase-2

    Ginkgo biloba has been reported to possess free radical-scavenging antioxidant activity and anti-inflammatory properties. In our pilot study, YY-1224, a terpene trilactone-strengthened...

    Zheng-Yi Li, Yoon Hee Chung, Eun-Joo Shin, Duy-Khanh Dang, Ji Hoon Jeong, Sung Kwon Ko, Seung-Yeol Nah, Tae Gon Baik, Jin Hyeong Jhoo, Wei-Yi Ong, Toshitaka Nabeshima and Hyoung-Chun Kim

    Journal of Neuroinflammation 2017 14:94

    Published on: 27 April 2017

  2. Research

    Polyunsaturated fatty acid receptors, GPR40 and GPR120, are expressed in the hypothalamus and control energy homeostasis and inflammation

    The consumption of large amounts of dietary fats is one of the most important environmental factors contributing to the development of obesity and metabolic disorders. GPR120 and GPR40 are polyunsaturated fatt...

    Nathalia R. V. Dragano, Carina Solon, Albina F. Ramalho, Rodrigo F. de Moura, Daniela S. Razolli, Elisabeth Christiansen, Carlos Azevedo, Trond Ulven and Licio A. Velloso

    Journal of Neuroinflammation 2017 14:91

    Published on: 26 April 2017

  3. Research

    Fingolimod attenuates experimental autoimmune neuritis and contributes to Schwann cell-mediated axonal protection

    Fingolimod, a sphingosine-1-phosphate receptor modulator with well-described immunomodulatory properties involving peripheral immune cell trafficking, was the first oral agent approved for the treatment of rel...

    Björn Ambrosius, Kalliopi Pitarokoili, Lisa Schrewe, Xiomara Pedreiturria, Jeremias Motte and Ralf Gold

    Journal of Neuroinflammation 2017 14:92

    Published on: 26 April 2017

  4. Research

    GlyCAM1 negatively regulates monocyte entry into the optic nerve head and contributes to radiation-based protection in glaucoma

    We previously reported a profound long-term neuroprotection subsequent to a single radiation-therapy in the DBA/2J mouse model of glaucoma. This neuroprotection prevents entry of monocyte-like immune cells int...

    Pete A. Williams, Catherine E. Braine, Nicole E. Foxworth, Kelly E. Cochran and Simon W. M. John

    Journal of Neuroinflammation 2017 14:93

    Published on: 26 April 2017

  5. Research

    Exercise attenuates neurological deficits by stimulating a critical HSP70/NF-κB/IL-6/synapsin I axis in traumatic brain injury rats

    Despite previous evidence for a potent inflammatory response after a traumatic brain injury (TBI), it is unknown whether exercise preconditioning (EP) improves outcomes after a TBI by modulating inflammatory r...

    Chung-Ching Chio, Hung-Jung Lin, Yu-Feng Tian, Yu-Chieh Chen, Mao-Tsun Lin, Cheng-Hsien Lin, Ching-Ping Chang and Chien-Chin Hsu

    Journal of Neuroinflammation 2017 14:90

    Published on: 24 April 2017

  6. Research

    Early strong intrathecal inflammation in cerebellar type multiple system atrophy by cerebrospinal fluid cytokine/chemokine profiles: a case control study

    The pathology of multiple system atrophy cerebellar-type (MSA-C) includes glial inflammation; however, cerebrospinal fluid (CSF) inflammatory cytokine profiles have not been investigated. In this study, we det...

    Ryo Yamasaki, Hiroo Yamaguchi, Takuya Matsushita, Takayuki Fujii, Akio Hiwatashi and Jun-ichi Kira

    Journal of Neuroinflammation 2017 14:89

    Published on: 24 April 2017

  7. Research

    Lack of interleukin-13 receptor α1 delays the loss of dopaminergic neurons during chronic stress

    The majority of Parkinson’s disease (PD) cases are sporadic and idiopathic suggesting that this neurodegenerative disorder is the result of both environmental and genetic factors. Stress and neuroinflammation ...

    Simone Mori, Shuei Sugama, William Nguyen, Tatiana Michel, M. Germana Sanna, Manuel Sanchez-Alavez, Rigo Cintron-Colon, Gianluca Moroncini, Yoshihiko Kakinuma, Pamela Maher and Bruno Conti

    Journal of Neuroinflammation 2017 14:88

    Published on: 21 April 2017

  8. Research

    Adiponectin levels in the serum and cerebrospinal fluid of amyotrophic lateral sclerosis patients: possible influence on neuroinflammation?

    Adiponectin (APN) is a key player in energy homeostasis strictly associated with cerebrovascular and neurodegenerative diseases. Since APN also belongs to anti-inflammatory-acting adipokines and may influence ...

    Patrizia Bossolasco, Raffaella Cancello, Alberto Doretti, Claudia Morelli, Vincenzo Silani and Lidia Cova

    Journal of Neuroinflammation 2017 14:85

    Published on: 20 April 2017

  9. Research

    TNF-α promotes extracellular vesicle release in mouse astrocytes through glutaminase

    Extracellular vesicles (EVs) are membrane-contained vesicles shed from cells. EVs contain proteins, lipids, and nucleotides, all of which play important roles in intercellular communication. The release of EVs...

    Kaizhe Wang, Ling Ye, Hongfang Lu, Huili Chen, Yanyan Zhang, Yunlong Huang and Jialin C. Zheng

    Journal of Neuroinflammation 2017 14:87

    Published on: 20 April 2017

  10. Research

    Toll-like receptor 4 in glial inflammatory responses to air pollution in vitro and in vivo

    Exposure to traffic-related air pollution (TRAP) is associated with accelerated cognitive aging and higher dementia risk in human populations. Rodent brains respond to TRAP with activation of astrocytes and mi...

    Nicholas C. Woodward, Morgan C. Levine, Amin Haghani, Farimah Shirmohammadi, Arian Saffari, Constantinos Sioutas, Todd E. Morgan and Caleb E. Finch

    Journal of Neuroinflammation 2017 14:84

    Published on: 14 April 2017

  11. Research

    Mu-opioid receptor and delta-opioid receptor differentially regulate microglial inflammatory response to control proopiomelanocortin neuronal apoptosis in the hypothalamus: effects of neonatal alcohol

    Opioid receptors are known to control neurotransmission of various peptidergic neurons, but their potential role in regulation of microglia and neuronal cell communications is unknown. We investigated the role...

    Pallavi Shrivastava, Miguel A. Cabrera, Lucy G. Chastain, Nadka I. Boyadjieva, Shaima Jabbar, Tina Franklin and Dipak K. Sarkar

    Journal of Neuroinflammation 2017 14:83

    Published on: 14 April 2017

  12. Research

    The PD-1: PD-L1 pathway promotes development of brain-resident memory T cells following acute viral encephalitis

    Previous work from our laboratory has demonstrated that during acute viral brain infection, glial cells modulate antiviral T cell effector responses through the PD-1: PD-L1 pathway, thereby limiting the delete...

    Sujata Prasad, Shuxian Hu, Wen S. Sheng, Priyanka Chauhan, Amar Singh and James R. Lokensgard

    Journal of Neuroinflammation 2017 14:82

    Published on: 13 April 2017

  13. Research

    Effects of environmental enrichment on white matter glial responses in a mouse model of chronic cerebral hypoperfusion

    This study was designed to explore the beneficial effects of environmental enrichment (EE) on white matter glial changes in a mouse model of chronic cerebral hypoperfusion induced by bilateral common carotid a...

    Yoshiki Hase, Lucinda Craggs, Mai Hase, William Stevenson, Janet Slade, Dianne Lopez, Rubin Mehta, Aiqing Chen, Di Liang, Arthur Oakley, Masafumi Ihara, Karen Horsburgh and Raj N. Kalaria

    Journal of Neuroinflammation 2017 14:81

    Published on: 11 April 2017

  14. Research

    The involvement of mast cells in the irinotecan-induced enteric neurons loss and reactive gliosis

    The irinotecan (CPT-11) causes intestinal mucositis and diarrhea that may be related to changes in the enteric nervous system (ENS). In inflammatory condition, mast cells release a variety of pro-inflammatory ...

    Ludmila T. Nogueira, Deiziane V. S. Costa, Antoniella S. Gomes, Conceição S. Martins, Angeline M. H. P. Silva, Juliana M. Coelho-Aguiar, Patrícia Castelucci, Roberto C. P. Lima-Júnior, Renata F. C. Leitão, Vivaldo Moura-Neto and Gerly A. C. Brito

    Journal of Neuroinflammation 2017 14:79

    Published on: 7 April 2017

  15. Research

    Diffusion MRI quantifies early axonal loss in the presence of nerve swelling

    Magnetic resonance imaging markers have been widely used to detect and quantify white matter pathologies in multiple sclerosis. We have recently developed a diffusion basis spectrum imaging (DBSI) to distingui...

    Tsen-Hsuan Lin, Chia-Wen Chiang, Carlos J. Perez-Torres, Peng Sun, Michael Wallendorf, Robert E. Schmidt, Anne H. Cross and Sheng-Kwei Song

    Journal of Neuroinflammation 2017 14:78

    Published on: 7 April 2017

  16. Research

    Exposure to gestational diabetes mellitus induces neuroinflammation, derangement of hippocampal neurons, and cognitive changes in rat offspring

    Birth cohort studies link gestational diabetes mellitus (GDM) with impaired cognitive performance in the offspring. However, the mechanisms involved are unknown. We tested the hypothesis that obesity-associate...

    Billy Vuong, Gary Odero, Stephanie Rozbacher, Mackenzie Stevenson, Stephanie M. Kereliuk, Troy J. Pereira, Vernon W. Dolinsky and Tiina M. Kauppinen

    Journal of Neuroinflammation 2017 14:80

    Published on: 7 April 2017

  17. Erratum

    Erratum to: Mannose-binding lectin-associated serine protease 2 (MASP-2) contributes to poor disease outcome in humans and mice with pneumococcal meningitis

    E. Soemirien Kasanmoentalib, Mercedes Valls Seron, Bart Ferwerda, Michael W. Tanck, Aeilko H. Zwinderman, Frank Baas, Arie van der Ende, William J. Schwaeble, Matthijs C. Brouwer and Diederik van de Beek

    Journal of Neuroinflammation 2017 14:77

    Published on: 6 April 2017

    The original article was published in Journal of Neuroinflammation 2017 14:2

  18. Research

    Retention of normal glia function by an isoform-selective protein kinase inhibitor drug candidate that modulates cytokine production and cognitive outcomes

    Brain p38α mitogen-activated protein kinase (MAPK), a potential therapeutic target for cognitive dysfunction based on the neuroinflammation-synaptic dysfunction cycle of pathophysiology progression, offers an ...

    Zhengqiu Zhou, Adam D. Bachstetter, Claudia B. Späni, Saktimayee M. Roy, D. Martin Watterson and Linda J. Van Eldik

    Journal of Neuroinflammation 2017 14:75

    Published on: 5 April 2017

  19. Research

    Microglia activation is essential for BMP7-mediated retinal reactive gliosis

    Our previous studies have shown that BMP7 is able to trigger activation of retinal macroglia. However, these studies showed the responsiveness of Müller glial cells and retinal astrocytes in vitro was attenuat...

    Subramanian Dharmarajan, Debra L. Fisk, Christine M. Sorenson, Nader Sheibani and Teri L. Belecky-Adams

    Journal of Neuroinflammation 2017 14:76

    Published on: 5 April 2017

  20. Research

    Grape seed-derived procyanidins alleviate gout pain via NLRP3 inflammasome suppression

    Gout is one of the common inflammatory arthritis which affects many people for inflicting unbearable pain. Macrophage-mediated inflammation plays an important role in gout. The uptake of monosodium urate (MSU)...

    Hai-Jiao Liu, Xiu-Xiu Pan, Bing-Qian Liu, Xuan Gui, Liang Hu, Chun-Yi Jiang, Yuan Han, Yi-Xin Fan, Yu-Lin Tang and Wen-Tao Liu

    Journal of Neuroinflammation 2017 14:74

    Published on: 4 April 2017

  21. Case report

    Atypical periodic alternating nystagmus responding to high-dose intravenous immunoglobulins: a case report

    Acquired periodic alternating nystagmus (PAN) is a rare but well-defined syndrome that consists of a horizontal nystagmus that cyclically reverses its direction. PAN can be caused by degenerative, neoplastic, ...

    Herminia Argente-Escrig, Luis Bataller, Claudio Krstulovic Roa, Vanesa Pérez Guillén, Herminio Perez Garrigues and Bonaventura Casanova Estruch

    Journal of Neuroinflammation 2017 14:71

    Published on: 31 March 2017

  22. Research

    Cytokine cascades induced by mechanical trauma injury alter voltage-gated sodium channel activity in intact cortical neurons

    Traumatic brain injury (TBI) triggers both immediate (primary) and long-term (secondary) tissue damages. Secondary damages can last from hours to days or even a lifetime. Secondary damages implicate several me...

    Weiqiang Chen, Jiangtao Sheng, Jingfang Guo, Guoyi Peng, Jinfang Hong, Bingbing Li, Xiaoxuan Chen, Kangsheng Li and Shousen Wang

    Journal of Neuroinflammation 2017 14:73

    Published on: 31 March 2017

  23. Research

    Cerebrospinal fluid cell-free mitochondrial DNA is associated with HIV replication, iron transport, and mild HIV-associated neurocognitive impairment

    Mitochondria are abundant organelles critical for energy metabolism and brain function. Mitochondrial DNA (mtDNA), released during cellular injury and as part of the innate immune response to viral pathogens, ...

    Sanjay R. Mehta, Josué Pérez-Santiago, Todd Hulgan, Tyler R. C. Day, Jill Barnholtz-Sloan, Haley Gittleman, Scott Letendre, Ronald Ellis, Robert Heaton, Stephanie Patton, Jesse D. Suben, Donald Franklin, Debralee Rosario, David B. Clifford, Ann C. Collier, Christina M. Marra…

    Journal of Neuroinflammation 2017 14:72

    Published on: 31 March 2017

  24. Research

    Suppression of MyD88-dependent signaling alleviates neuropathic pain induced by peripheral nerve injury in the rat

    MyD88 is the adaptor protein of MyD88-dependent signaling pathway of TLRs and IL-1 receptor and regulates innate immune response. However, it was not clear whether and how MyD88 and related signaling pathways ...

    Fan Liu, Zhiyao Wang, Yue Qiu, Min Wei, Chunyan Li, Yikuan Xie, Le Shen, Yuguang Huang and Chao Ma

    Journal of Neuroinflammation 2017 14:70

    Published on: 31 March 2017

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