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  1. Diabetes-associated cognitive impairment (DACI) poses a significant challenge to the self-management of diabetes, markedly elevating the risk of adverse complications. A burgeoning body of evidence implicates ...

    Authors: Wen-yuan Zhang, Qian-qian Wei, Tao Zhang, Chang-shui Wang, Jing Chen, Jian-hua Wang, Xin Xie and Pei Jiang
    Citation: Journal of Neuroinflammation 2024 21:177
  2. Accumulating evidence implicates that herpes simplex virus type 1 (HSV-1) has been linked to the development and progression of Alzheimer’s disease (AD). HSV-1 infection induces β-amyloid (Aβ) deposition in vi...

    Authors: Zhimeng Wang, Jing Liu, Jing Han, Tianyi Zhang, Shangjin Li, Yanfei Hou, Huili Su, Fangping Han and Conggang Zhang
    Citation: Journal of Neuroinflammation 2024 21:176
  3. Key functions of Ca2+ signaling in rodent microglia include monitoring the brain state as well as the surrounding neuronal activity and sensing the danger or damage in their vicinity. Microglial Ca2+ dyshomeostas...

    Authors: Sofia Nevelchuk, Bianca Brawek, Niklas Schwarz, Ariel Valiente-Gabioud, Thomas V. Wuttke, Yury Kovalchuk, Henner Koch, Anke Höllig, Frederik Steiner, Katherine Figarella, Oliver Griesbeck and Olga Garaschuk
    Citation: Journal of Neuroinflammation 2024 21:175
  4. Specific microglia responses are thought to contribute to the development and progression of neurodegenerative diseases, including Parkinson’s disease (PD). However, the phenotypic acquisition of microglial ce...

    Authors: Frida Lind-Holm Mogensen, Carole Sousa, Corrado Ameli, Katja Badanjak, Sandro L. Pereira, Arnaud Muller, Tony Kaoma, Djalil Coowar, Andrea Scafidi, Suresh K. Poovathingal, Maria Tziortziou, Paul M. A. Antony, Nathalie Nicot, Aurélien Ginolhac, Daniela M. Vogt Weisenhorn, Wolfgang Wurst…
    Citation: Journal of Neuroinflammation 2024 21:174
  5. Dietary patterns that include an excess of foods rich in saturated fat are associated with brain dysfunction. Although microgliosis has been proposed to play a key role in the development of brain dysfunction ...

    Authors: Gabriela C. De Paula, Blanca I. Aldana, Roberta Battistella, Rosalía Fernández-Calle, Andreas Bjure, Iben Lundgaard, Tomas Deierborg and João M. N. Duarte
    Citation: Journal of Neuroinflammation 2024 21:173
  6. Post-traumatic epilepsy (PTE) is one of the most debilitating consequences of traumatic brain injury (TBI) and is one of the most drug-resistant forms of epilepsy. Novel therapeutic treatment options are an ur...

    Authors: Mohit Javalgekar, Bianca Jupp, Lucy Vivash, Terence J. O’Brien, David K. Wright, Nigel C. Jones and Idrish Ali
    Citation: Journal of Neuroinflammation 2024 21:172
  7. White matter injury (WMI) is thought to be a major contributor to long-term cognitive dysfunctions after traumatic brain injury (TBI). This damage occurs partly due to apoptotic death of oligodendrocyte lineag...

    Authors: Kirill Shumilov, Allen Ni, Maria Garcia-Bonilla, Marta Celorrio and Stuart H. Friess
    Citation: Journal of Neuroinflammation 2024 21:171
  8. Ischemia-induced retinopathy is a hallmark finding of common visual disorders including diabetic retinopathy (DR) and central retinal artery and vein occlusions. Treatments for ischemic retinopathies fail to i...

    Authors: Rami A. Shahror, Esraa Shosha, Carol Morris, Melissa Wild, Shengyu Mu, Gabor Csanyi, Marjan Boerma, Nancy J. Rusch and Abdelrahman Y. Fouda
    Citation: Journal of Neuroinflammation 2024 21:170
  9. Understanding the mechanism behind sepsis-associated encephalopathy (SAE) remains a formidable task. This study endeavors to shed light on the complex cellular and molecular alterations that occur in the brain...

    Authors: Yanyan Zhu, Yin Zhang, Sheng He, Sanjun Yi, Hao Feng, Xianzhu Xia, Xiaodong Fang, Xiaoqian Gong and Pingsen Zhao
    Citation: Journal of Neuroinflammation 2024 21:169
  10. The eye is a highly specialized sensory organ which encompasses the retina as a part of the central nervous system, but also non-neural compartments such as the transparent vitreous body ensuring stability of ...

    Authors: Dennis-Dominik Rosmus, Jana Koch, Annika Hausmann, Aude Chiot, Franz Arnhold, Takahiro Masuda, Katrin Kierdorf, Stefanie Marie Hansen, Heidrun Kuhrt, Janine Fröba, Julian Wolf, Stefaniya Boneva, Martin Gericke, Bahareh Ajami, Marco Prinz, Clemens Lange…
    Citation: Journal of Neuroinflammation 2024 21:168
  11. Deposition of amyloid β, which is produced by amyloidogenic cleavage of APP by β- and γ-secretase, is one of the primary hallmarks of AD pathology. APP can also be processed by α- and γ-secretase sequentially,...

    Authors: Chao Song, Shufang Li, Yingren Mai, Linpeng Li, Guoku Dai, Yuan Zhou, Xiaosheng Liang, Olivia Meilan Zou, Ya Wang, Libing Zhou, Jun Liu and Yi Zou
    Citation: Journal of Neuroinflammation 2024 21:167
  12. Type 2 diabetes mellitus (T2DM) and obstructive sleep apnea (OSA) are mutual risk factors, with both conditions inducing cognitive impairment and anxiety. However, whether OSA exacerbates cognitive impairment ...

    Authors: Wenyu Ni, Yun Niu, Sitong Cao, Chunsun Fan, Jian Fan, Li Zhu and Xueting Wang
    Citation: Journal of Neuroinflammation 2024 21:166
  13. Traumatic brain injury (TBI) is a significant risk factor for Alzheimer’s disease (AD), and accumulating evidence supports a role for adaptive immune B and T cells in both TBI and AD pathogenesis. We previousl...

    Authors: Jaclyn Iannucci, Reagan Dominy, Shreya Bandopadhyay, E. Madison Arthur, Brenda Noarbe, Amandine Jullienne, Margret Krkasharyan, Richard P. Tobin, Aleksandr Pereverzev, Samantha Beevers, Lavanya Venkatasamy, Karienn A. Souza, Daniel C. Jupiter, Alan Dabney, Andre Obenaus, M. Karen Newell-Rogers…
    Citation: Journal of Neuroinflammation 2024 21:165
  14. The microglia-mediated neuroinflammation have been shown to play a crucial role in the ocular pathological angiogenesis process, but specific immunotherapies for neovascular ocular diseases are still lacking. ...

    Authors: Biyan Ni, Ziqi Yang, Tian Zhou, Hong Zhou, Yang Zhou, Shiya Lin, Huiyi Xu, Xiaojing Lin, Wei Yi, Chang He and Xialin Liu
    Citation: Journal of Neuroinflammation 2024 21:164
  15. The SARS-CoV-2 virus activates maternal and placental immune responses. Such activation in the setting of other infections during pregnancy is known to impact fetal brain development. The effects of maternal i...

    Authors: Lydia L. Shook, Rebecca E. Batorsky, Rose M. De Guzman, Liam T. McCrea, Sara M. Brigida, Joy E. Horng, Steven D. Sheridan, Olha Kholod, Aidan M. Cook, Jonathan Z. Li, Donna K. Slonim, Brittany A. Goods, Roy H. Perlis and Andrea G. Edlow
    Citation: Journal of Neuroinflammation 2024 21:163
  16. Radiation retinopathy (RR) is a major side effect of ocular tumor treatment by plaque brachytherapy or proton beam therapy. RR manifests as delayed and progressive microvasculopathy, ischemia and macular edema...

    Authors: Cécile Lebon, Denis Malaise, Nicolas Rimbert, Manon Billet, Gabriel Ramasamy, Jérémie Villaret, Frédéric Pouzoulet, Alexandre Matet and Francine Behar-Cohen
    Citation: Journal of Neuroinflammation 2024 21:162
  17. Pediatric acute transverse myelitis (ATM) accounts for 20–30% of children presenting with a first acquired demyelinating syndrome (ADS) and may be the first clinical presentation of a relapsing ADS such as mul...

    Authors: Chad Smith, Kiel M. Telesford, Sara G. M. Piccirillo, Yamhilette Licon-Munoz, Wei Zhang, Key M. Tse, Jacqueline R. Rivas, Chaitanya Joshi, Dilan S. Shah, Angela X. Wu, Ritu Trivedi, Scott Christley, Yu Qian, Lindsay G. Cowell, Richard H. Scheuermann, Ann M. Stowe…
    Citation: Journal of Neuroinflammation 2024 21:161
  18. Authors: Marina Leardini-Tristão, Giulia Andrade, Celina Garcia, Patrícia A. Reis, Millena Lourenço, Emilio T. S. Moreira, Flavia R. S. Lima, Hugo C. Castro-Faria-Neto, Eduardo Tibirica and Vanessa Estato
    Citation: Journal of Neuroinflammation 2024 21:160

    The original article was published in Journal of Neuroinflammation 2020 17:117

  19. Respiratory infections are one of the most common causes of illness and morbidity in neonates worldwide. In the acute phase infections are known to cause wide-spread peripheral inflammation. However, the infla...

    Authors: Kateleen E Hedley, Henry M Gomez, Eda Kecelioglu, Olivia R Carroll, Phillip Jobling, Jay C Horvat and Melissa A Tadros
    Citation: Journal of Neuroinflammation 2024 21:158
  20. Cystatin F is a secreted lysosomal cysteine protease inhibitor that has been implicated in affecting the severity of demyelination and enhancing remyelination in pre-clinical models of immune-mediated demyelin...

    Authors: Amber R. Syage, Collin Pachow, Kaitlin M. Murray, Caden Henningfield, Kellie Fernandez, Annie Du, Yuting Cheng, Gema Olivarria, Shimako Kawauchi, Grant R. MacGregor, Kim N. Green and Thomas E. Lane
    Citation: Journal of Neuroinflammation 2024 21:157
  21. Repetitive mild traumatic brain injuries (rmTBI) sustained within a window of vulnerability can result in long term cognitive deficits, depression, and eventual neurodegeneration associated with tau pathology,...

    Authors: Alyssa F. Pybus, Sara Bitarafan, Rowan O. Brothers, Alivia Rohrer, Arushi Khaitan, Felix Rivera Moctezuma, Kareena Udeshi, Brae Davies, Sydney Triplett, Martin N. Griffin, Eric B. Dammer, Srikant Rangaraju, Erin M. Buckley and Levi B. Wood
    Citation: Journal of Neuroinflammation 2024 21:156
  22. Activation of the kallikrein-kinin system promotes vascular leakage, inflammation, and neurodegeneration in ischemic stroke. Inhibition of plasma kallikrein (PK) – a key component of the KKS – in the acute pha...

    Authors: Steffen Haupeltshofer, Stine Mencl, Rebecca D. Szepanowski, Christina Hansmann, Ana I. Casas, Hanna Abberger, Wiebke Hansen, Alina Blusch, Cornelius Deuschl, Michael Forsting, Dirk M. Hermann, Friederike Langhauser and Christoph Kleinschnitz
    Citation: Journal of Neuroinflammation 2024 21:155
  23. Extracellular vesicles (EVs) are released by all cells, can cross the blood–brain barrier, and have been shown to play an important role in cellular communication, substance shuttling, and immune modulation. I...

    Authors: Larissa Jank, Ajay Kesharwani, Taekyung Ryu, Deepika Joshi, Dimitrios C. Ladakis, Matthew D. Smith, Saumitra Singh, Tanina Arab, Kenneth W. Witwer, Peter A. Calabresi, Chan-Hyun Na and Pavan Bhargava
    Citation: Journal of Neuroinflammation 2024 21:154
  24. Parkinson’s disease (PD) is a prevalent neurodegenerative disorder with indistinct etiology and ill-defined pathophysiology. Intestinal inflammation involved in the pathogenesis of PD, but the underlying mecha...

    Authors: Yongtao He, Jiayin Zhao, Yuanyuan Ma, Xin Yan, Yufei Duan, Xiaoshuang Zhang, Hongtian Dong, Rong Fang, Yunhe Zhang, Qing Li, Ping Yang, Mei Yu, Jian Fei and Fang Huang
    Citation: Journal of Neuroinflammation 2024 21:153
  25. Mounting evidence links glucose intolerance and diabetes as aspects of metabolic dysregulation that are associated with an increased risk of developing dementia. Inflammation and inflammasome activation have e...

    Authors: Rasa Valiauga, Sarah Talley, Mark Khemmani, Melline Fontes Noronha, Rocco Gogliotti, Alan J. Wolfe and Edward Campbell
    Citation: Journal of Neuroinflammation 2024 21:151
  26. Microglia, the brain’s resident macrophages, maintain brain homeostasis and respond to injury and infection. During aging they undergo functional changes, but the underlying mechanisms and their contributions ...

    Authors: Seokjo Kang, Emily Y. Ko, Amelia E. Andrews, Juliana E. Shin, Karina J. Nance, Pijus K. Barman, Peter S. Heeger, Willard M. Freeman, Bérénice A. Benayoun and Helen S. Goodridge
    Citation: Journal of Neuroinflammation 2024 21:150
  27. Uncontrolled neuroinflammation mediates traumatic brain injury (TBI) pathology and impairs recovery. Interleukin-6 (IL-6), a pleiotropic inflammatory regulator, is associated with poor clinical TBI outcomes. I...

    Authors: Ian G. Gober, Ashley L. Russell, Tyler J. Shick, Vincent A. Vagni, Jenna C. Carlson, Patrick M. Kochanek and Amy K. Wagner
    Citation: Journal of Neuroinflammation 2024 21:149
  28. White matter injury (WMI) represents a significant etiological factor contributing to neurological impairment subsequent to Traumatic Brain Injury (TBI). CD36 receptors are recognized as pivotal participants i...

    Authors: Xiaoxiang Hou, Xiaolin Qu, Wen Chen, Xianzheng Sang, Yichao Ye, Chengqing Wang, Yangu Guo, Hantong Shi, Chengzi Yang, Kaixin Zhu, Yelei Zhang, Haoxiang Xu, Liquan Lv, Danfeng Zhang and Lijun Hou
    Citation: Journal of Neuroinflammation 2024 21:148
  29. The gut microbiota plays a critical role in regulating brain function through the microbiome-gut-brain axis (MGBA). Dysbiosis of the gut microbiota is associated with neurological impairment in Traumatic brain...

    Authors: Nina Gu, Jin Yan, Wei Tang, Zhaosi Zhang, Lin Wang, Zhao Li, Yingwen Wang, Yajun Zhu, Shuang Tang, Jianjun Zhong, Chongjie Cheng, Xiaochuan Sun and Zhijian Huang
    Citation: Journal of Neuroinflammation 2024 21:147
  30. T cells play an important role in the acquired immune response, with regulatory T cells (Tregs) serving as key players in immune tolerance. Tregs are found in nonlymphoid and damaged tissues and are referred t...

    Authors: Mahiro Watanabe, Ako Matsui, Natsumi Awata, Ayame Nagafuchi, Mio Kawazoe, Yoshihiro Harada and Minako Ito
    Citation: Journal of Neuroinflammation 2024 21:146
  31. Recent experimental studies of neuroinflammation in glaucoma pointed to cFLIP as a molecular switch for cell fate decisions, mainly regulating cell type-specific caspase-8 functions in cell death and inflammat...

    Authors: Xiangjun Yang, Qun Zeng, Maide Gözde İnam, Onur İnam, Chyuan-Sheng Lin and Gülgün Tezel
    Citation: Journal of Neuroinflammation 2024 21:145
  32. Cumulative evidence has established that Interferon (IFN)-γ has both pathogenic and protective roles in Multiple Sclerosis and the animal model, Experimental Autoimmune Encephalomyelitis (EAE). However, the un...

    Authors: Gabriel Arellano, Eric Acuña, Eileah Loda, Lindsay Moore, Juan E. Tichauer, Cristian Castillo, Fabian Vergara, Paula I. Burgos, Pablo Penaloza-MacMaster, Stephen D. Miller and Rodrigo Naves
    Citation: Journal of Neuroinflammation 2024 21:144
  33. The dysregulation of pro- and anti-inflammatory processes in the brain has been linked to the pathogenesis of major depressive disorder (MDD), although the precise mechanisms remain unclear. In this study, we ...

    Authors: Yuan Li, Bing Zhan, Xiao Zhuang, Ming Zhao, Xiaotong Chen, Qun Wang, Qiji Liu and Lining Zhang
    Citation: Journal of Neuroinflammation 2024 21:143
  34. Intrauterine inflammation is considered a major cause of brain injury in preterm infants, leading to long-term neurodevelopmental deficits. A potential contributor to this brain injury is dysregulation of neur...

    Authors: Nhi T. Tran, Nadia Hale, Anawar Aung Win Maung, Manon Wiersma, David W. Walker, Graeme Polglase, Margie Castillo-Melendez and Flora Y. Wong
    Citation: Journal of Neuroinflammation 2024 21:142
  35. The lectin pathway (LP) of complement mediates inflammatory processes linked to tissue damage and loss of function following traumatic brain injury (TBI). LP activation triggers a cascade of proteolytic events...

    Authors: Domenico Mercurio, Francesca Pischiutta, Serena Seminara, Francesca Tribuzio, Ilaria Lisi, Laura Pasetto, Valentina Bonetto, Maria-Grazia De Simoni, Wilhelm Schwaeble, Sadam Yaseen, Thomas Dudler, Elisa R. Zanier and Stefano Fumagalli
    Citation: Journal of Neuroinflammation 2024 21:141
  36. Perihematomal edema (PHE) after post-intracerebral hemorrhage (ICH) has complex pathophysiological mechanisms that are poorly understood. The complicated immune response in the post-ICH brain constitutes a cru...

    Authors: Peng Zhang, Cong Gao, Qiang Guo, Dongxu Yang, Guangning Zhang, Hao Lu, Liman Zhang, Guorong Zhang and Daojing Li
    Citation: Journal of Neuroinflammation 2024 21:140
  37. Authors: Michela Campolo, Emanuela Esposito, Akbar Ahmad, Rosanna Di Paola, Irene Paterniti, Marika Cordaro, Giuseppe Bruschetta, John L. Wallace and Salvatore Cuzzocrea
    Citation: Journal of Neuroinflammation 2024 21:139

    The original article was published in Journal of Neuroinflammation 2014 11:196

  38. Sepsis-associated encephalopathy (SAE) is a significant cause of mortality in patients with sepsis. Despite extensive research, its exact cause remains unclear. Our previous research indicated a relationship b...

    Authors: Lina Zhao, Zhen Zhang, Pei Wang, Nannan Zhang, Hao shen, Hening Wu, Zhiyong Wei, Fei Yang, Yunying Wang, Zhijie Yu, Haibo Li, Zhanfei Hu, Hongyan Zhai, Zhiwei Wang, Fuhong Su, Keliang Xie…
    Citation: Journal of Neuroinflammation 2024 21:138
  39. Hyperglycemia has been shown to modulate the immune response of peripheral immune cells and organs, but the impact of hyperglycemia on neuroinflammation within the brain remains elusive. In the present study, ...

    Authors: Kyung-Seo Lee, Sung-Hyun Yoon, Inhwa Hwang, Jeong-Hwa Ma, Euimo Yang, Rebekah Hyeyoon Kim, Eosu Kim and Je-Wook Yu
    Citation: Journal of Neuroinflammation 2024 21:137
  40. Autoimmune uveitis is a leading cause of severe vision loss, and animal models provide unique opportunities for studying its pathogenesis and therapeutic strategies. Here we employ scRNA-seq, RNA-seq and vario...

    Authors: Fa Yuan, Rong Zhang, Jiani Li, Qiannan Lei, Shuyi Wang, Fanying Jiang, Yanan Guo and Mengqing Xiang
    Citation: Journal of Neuroinflammation 2024 21:136
  41. Since the 1990s, evidence has accumulated that macrophages promote peripheral nerve regeneration and are required for enhancing regeneration in the conditioning lesion (CL) response. After a sciatic nerve inju...

    Authors: Aaron D. Talsma, Jon P. Niemi and Richard E. Zigmond
    Citation: Journal of Neuroinflammation 2024 21:134
  42. Neonatal hypoxic-ischemic encephalopathy (HIE) is one of the most common neurological problems occurring in the perinatal period. However, there still is not a promising approach to reduce long-term neurodevel...

    Authors: Yanping Yang, Yang Li, Wenyi Yang, Xueying Yang, Man Luo, Ling Qin and Junchao Zhu
    Citation: Journal of Neuroinflammation 2024 21:132
  43. Sepsis-associated encephalopathy (SAE) causes acute and long-term cognitive deficits. However, information on the prevention and treatment of cognitive dysfunction after sepsis is limited. The neuropeptide ore...

    Authors: Jing Guo, Zhuo Kong, Sha Yang, Jingjing Da, Liangzhao Chu, Guoqiang Han, Jian Liu, Ying Tan and Jiqin Zhang
    Citation: Journal of Neuroinflammation 2024 21:131
  44. Epidemiological studies have unveiled a robust link between exposure to repetitive mild traumatic brain injury (r-mTBI) and elevated susceptibility to develop neurodegenerative disorders, notably chronic traum...

    Authors: Camila Ortiz, Andrew Pearson, Robyn McCartan, Shawn Roche, Nolan Carothers, Mackenzie Browning, Sylvia Perez, Bin He, Stephen D. Ginsberg, Michael Mullan, Elliott J. Mufson, Fiona Crawford and Joseph Ojo
    Citation: Journal of Neuroinflammation 2024 21:130
  45. Diet-induced increase in body weight is a growing health concern worldwide. Often accompanied by a low-grade metabolic inflammation that changes systemic functions, diet-induced alterations may contribute to n...

    Authors: Marilena Poxleitner, Sabrina H. L. Hoffmann, Georgy Berezhnoy, Tudor M. Ionescu, Irene Gonzalez-Menendez, Florian C. Maier, Dominik Seyfried, Walter Ehrlichmann, Leticia Quintanilla-Martinez, Andreas M. Schmid, Gerald Reischl, Christoph Trautwein, Andreas Maurer, Bernd J. Pichler, Kristina Herfert and Nicolas Beziere
    Citation: Journal of Neuroinflammation 2024 21:129
  46. Multiple sclerosis (MS) is a progressive neurodegenerative disease of the central nervous system characterized by inflammation-driven synaptic abnormalities. Interleukin-9 (IL-9) is emerging as a pleiotropic c...

    Authors: Livia Guadalupi, Valentina Vanni, Sara Balletta, Silvia Caioli, Francesca De Vito, Diego Fresegna, Krizia Sanna, Monica Nencini, Gloria Donninelli, Elisabetta Volpe, Fabrizio Mariani, Luca Battistini, Mario Stampanoni Bassi, Luana Gilio, Antonio Bruno, Ettore Dolcetti…
    Citation: Journal of Neuroinflammation 2024 21:128

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  • Citation Impact 2023
    Journal Impact Factor: 9.3
    5-year Journal Impact Factor: 9.8
    Source Normalized Impact per Paper (SNIP): 1.787
    SCImago Journal Rank (SJR): 2.831

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    Submission to first editorial decision (median days): 11
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