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  1. Content type: Research

    Epilepsy is a common neurological disorder and is not well controlled by available antiepileptic drugs (AEDs). Inflammation is considered to be a critical factor in the pathophysiology of epilepsy. Sinomenine ...

    Authors: Bo Gao, Yu Wu, Yuan-Jian Yang, Wei-Zu Li, Kun Dong, Jun Zhou, Yan-Yan Yin, Da-Ke Huang and Wen-Ning Wu

    Citation: Journal of Neuroinflammation 2018 15:152

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  2. Content type: Research

    Microglial polarization with M1/M2 phenotype shifts and the subsequent neuroinflammatory responses are vital contributing factors for spinal cord injury (SCI)-induced secondary injury. Nuclear factor-κB (NF-κB...

    Authors: Shoubo Chen, Jingfang Ye, Xiangrong Chen, Jinnan Shi, Wenhua Wu, Wenping Lin, Weibin Lin, Yasong Li, Huangde Fu and Shun Li

    Citation: Journal of Neuroinflammation 2018 15:150

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  3. Content type: Case report

    Rheumatoid meningitis (RM) is a rare disorder that often develops during a remission phase of rheumatoid arthritis (RA). This is the first study to demonstrate differences in regard to immunological disturbanc...

    Authors: Miki Oono, Yoshimasa Fujita, Nobuaki Uchida, Ukichiro Kawai, Michiyo Fujita-Nakata, Megumi Nakanishi, Mitsuru Sanada, Shigemi Nagayama and Makoto Matsui

    Citation: Journal of Neuroinflammation 2018 15:151

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  4. Content type: Review

    Our knowledge of the pathophysiology about traumatic brain injury (TBI) is still limited. Neutrophils, as the most abundant leukocytes in circulation and the first-line transmigrated immune cells at the sites ...

    Authors: Yang-Wuyue Liu, Song Li and Shuang-Shuang Dai

    Citation: Journal of Neuroinflammation 2018 15:146

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  5. Content type: Research

    Systemic inflammation induces neuroinflammation and cellular changes such as tau phosphorylation to impair cognitive function, including learning and memory. This study uses a single model, laparotomy without ...

    Authors: Chunxia Huang, Michael Garnet Irwin, Gordon Tin Chun Wong and Raymond Chuen Chung Chang

    Citation: Journal of Neuroinflammation 2018 15:147

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  6. Content type: Research

    Activation of transforming growth factor-β-activated kinase 1 (TAK1) occurs after stroke and leads to an exacerbation of brain injury. TAK1 is involved in innate and adaptive immune responses, but it has diver...

    Authors: Anjali Chauhan, Jacob Hudobenko, Abdullah Al Mamun, Edward C. Koellhoffer, Anthony Patrizz, Rodney M. Ritzel, Bhanu P. Ganesh and Louise D. McCullough

    Citation: Journal of Neuroinflammation 2018 15:148

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  7. Content type: Research

    Activation of microglia can result in phenotypic and functional diversity. However, the pathways that trigger different states of microglial activation remain to be fully understood. Here, we hypothesized that...

    Authors: Changhong Xing, Wenlu Li, Wenjun Deng, MingMing Ning and Eng H. Lo

    Citation: Journal of Neuroinflammation 2018 15:143

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  8. Content type: Review

    Epilepsy, a neurological disease characterized by recurrent seizures, is often associated with a history of previous lesions in the nervous system. Impaired regulation of the activation and resolution of infla...

    Authors: Amna Rana and Alberto E. Musto

    Citation: Journal of Neuroinflammation 2018 15:144

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  9. Content type: Research

    Immune checkpoint inhibitors have been shown to promote antitumor immunity and achieve durable tumor remissions. However, certain tumors are refractory to current immunotherapy. These negative results encourag...

    Authors: Peng-fei Wang, Hong-qing Cai, Chuan-bao Zhang, Yan-Michael Li, Xiang Liu, Jing-hai Wan, Tao Jiang, Shou-wei Li and Chang-Xiang Yan

    Citation: Journal of Neuroinflammation 2018 15:145

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  10. Content type: Research

    Microglial activation contributes to the neuropathology associated with chronic alcohol exposure and withdrawal, including the expression of inflammatory and anti-inflammatory genes. In the current study, we e...

    Authors: Sergey Kalinin, Marta González-Prieto, Hannah Scheiblich, Lucia Lisi, Handojo Kusumo, Michael T. Heneka, Jose L. M. Madrigal, Subhash C. Pandey and Douglas L. Feinstein

    Citation: Journal of Neuroinflammation 2018 15:141

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  11. Content type: Research

    Acute neurological insults caused by infection, systemic inflammation, ischemia, or traumatic injury are often associated with breakdown of the blood-brain barrier (BBB) followed by infiltration of peripheral ...

    Authors: Justin R. Piro, Georgette L. Suidan, Jie Quan, YeQing Pi, Sharon M. O’Neill, Marissa Ilardi, Nikolay Pozdnyakov, Thomas A. Lanz, Hualin Xi, Robert D. Bell and Tarek A. Samad

    Citation: Journal of Neuroinflammation 2018 15:142

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  12. Content type: Research

    Systemic inflammation associated with sepsis can induce neuronal hyperexcitability, leading to enhanced seizure predisposition and occurrence. Brain microglia are rapidly activated in response to systemic infl...

    Authors: Wan-Yu Huang, Shankung Lin, Hsuan-Ying Chen, Ya-Ping Chen, Ting-Yu Chen, Kuei-Sen Hsu and Hung-Ming Wu

    Citation: Journal of Neuroinflammation 2018 15:140

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  13. Content type: Research

    Pericytes and endothelial cells are critical cellular components of the blood-brain barrier (BBB) and play an important role in neuroinflammation. To date, the majority of inflammation-related studies in endot...

    Authors: Leon C. D. Smyth, Justin Rustenhoven, Thomas I.-H. Park, Patrick Schweder, Deidre Jansson, Peter A. Heppner, Simon J. O’Carroll, Edward W. Mee, Richard L. M. Faull, Maurice Curtis and Mike Dragunow

    Citation: Journal of Neuroinflammation 2018 15:138

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  14. Content type: Research

    Parkinson’s disease (PD) is characterized by selective degeneration of dopaminergic (DA) neurons of the substantia nigra pars compacta (SN) while neighboring ventral tegmental area (VTA) DA neurons are relativ...

    Authors: Eric Wildon Kostuk, Jingli Cai and Lorraine Iacovitti

    Citation: Journal of Neuroinflammation 2018 15:139

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  15. Content type: Research

    The mixed lineage kinase type 3 inhibitor URMC-099 facilitates amyloid-beta (Aβ) clearance and degradation in cultured murine microglia. One putative mechanism is an effect of URMC-099 on Aβ uptake and degrada...

    Authors: Tomomi Kiyota, Jatin Machhi, Yaman Lu, Bhagyalaxmi Dyavarshetty, Maryam Nemati, Gang Zhang, R. Lee Mosley, Harris A. Gelbard and Howard E. Gendelman

    Citation: Journal of Neuroinflammation 2018 15:137

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  16. Content type: Review

    Over the past few years, new-generation cell-based assays have demonstrated a robust association of autoantibodies to full-length human myelin oligodendrocyte glycoprotein (MOG-IgG) with (mostly recurrent) opt...

    Authors: S. Jarius, F. Paul, O. Aktas, N. Asgari, R. C. Dale, J. de Seze, D. Franciotta, K. Fujihara, A. Jacob, H. J. Kim, I. Kleiter, T. Kümpfel, M. Levy, J. Palace, K. Ruprecht, A. Saiz…

    Citation: Journal of Neuroinflammation 2018 15:134

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  17. Content type: Research

    Ischemic stroke induced matrixmetallo-proteinase-9 (MMP-9) upregulation, which increased blood-brain barrier permeability. Studies demonstrated that mesenchymal stem cell therapy protected blood-brain barrier ...

    Authors: Zhuo Cheng, Liping Wang, Meijie Qu, Huaibin Liang, Wanlu Li, Yongfang Li, Lidong Deng, Zhijun Zhang and Guo-Yuan Yang

    Citation: Journal of Neuroinflammation 2018 15:135

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  18. Content type: Research

    Chronic pro-inflammatory signaling propagates damage to neural tissue and affects the rate of disease progression. Increased activation of Toll-like receptors (TLRs), master regulators of the innate immune res...

    Authors: Sinéad Kinsella, Michael Fichtner, Orla Watters, Hans-Georg König and Jochen H. M. Prehn

    Citation: Journal of Neuroinflammation 2018 15:130

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  19. Content type: Research

    Depression is a frequent mood disorder in stroke patient. Our aim was to determine irisin levels in serum and investigate their associations with post-stroke depression (PSD) in a 6-month follow-up study in Ch...

    Authors: Wen-Jun Tu, Han-Cheng Qiu, Qiang Liu, Xuemei Li, Ji-Zong Zhao and Xianwei Zeng

    Citation: Journal of Neuroinflammation 2018 15:133

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  20. Content type: Research

    Numerous studies suggested that PM2.5 exposure was associated with increased risk of Alzheimer’s disease (AD). But the precise mechanisms by which PM2.5 contributed to AD pathogenesis have not been clarified.

    Authors: Bian-Rong Wang, Jian-Quan Shi, Nian-Nian Ge, Zhou Ou, You-Yong Tian, Teng Jiang, Jun-Shan Zhou, Jun Xu and Ying-Dong Zhang

    Citation: Journal of Neuroinflammation 2018 15:132

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  21. Content type: Research

    Multiple risk factors contribute to the progression of Parkinson’s disease, including oxidative stress and neuroinflammation. Epidemiological studies have revealed a link between higher urate level and a lower...

    Authors: Li-Hui Bao, Ya-Nan Zhang, Jian-Nan Zhang, Li Gu, Hui-Min Yang, Yi-Ying Huang, Ning Xia and Hong Zhang

    Citation: Journal of Neuroinflammation 2018 15:131

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  22. Content type: Research

    Converging evidence suggests a role for microglia-mediated neuroinflammation in Parkinson’s disease (PD). Animal models of PD can serve as a platform to investigate the role of neuroinflammation in degeneratio...

    Authors: Megan F. Duffy, Timothy J. Collier, Joseph R. Patterson, Christopher J. Kemp, Kelvin C. Luk, Malú G. Tansey, Katrina L. Paumier, Nicholas M. Kanaan, Luke D. Fischer, Nicole K. Polinski, Olivia L. Barth, Jacob W. Howe, Nishant N. Vaikath, Nour K. Majbour, Omar M. A. El-Agnaf and Caryl E. Sortwell

    Citation: Journal of Neuroinflammation 2018 15:129

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  23. Content type: Research

    Vascular adhesion protein-1 (VAP-1) is an inflammation-inducible endothelial cell molecule and primary amine oxidase that mediates leukocyte entry to sites of inflammation. However, there is limited knowledge ...

    Authors: Petri Elo, Sina Tadayon, Heidi Liljenbäck, Jarmo Teuho, Meeri Käkelä, Kalle Koskensalo, Virva Saunavaara, Jenni Virta, Tibor Z. Veres, Aida Kiviniemi, Antti Saraste, Päivi Marjamäki, Laura Airas, Sirpa Jalkanen and Anne Roivainen

    Citation: Journal of Neuroinflammation 2018 15:128

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