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  1. Microglia/macrophages are activated after cerebral ischemic stroke and can contribute to either brain injury or recovery by polarizing microglia/macrophage into distinctive functional phenotypes with pro- or a...

    Authors: Di Chen, Jiaying Li, Yichen Huang, Pengju Wei, Wanying Miao, Yaomei Yang and Yanqin Gao
    Citation: Journal of Neuroinflammation 2022 19:112
  2. Microglia are the tissue-resident macrophages of the CNS. They originate in the yolk sac, colonize the CNS during embryonic development and form a self-sustaining population with limited turnover. A consequenc...

    Authors: Xiaoming Zhang, Laura Kracht, Antonio M. Lerario, Marissa L. Dubbelaar, Nieske Brouwer, Evelyn M. Wesseling, Erik W. G. M. Boddeke, Bart J. L. Eggen and Susanne M. Kooistra
    Citation: Journal of Neuroinflammation 2022 19:111
  3. Approximately 70% of Alzheimer’s disease (AD) patients have co-morbid vascular contributions to cognitive impairment and dementia (VCID); this highly prevalent overlap of dementia subtypes is known as mixed de...

    Authors: Olivia J. Gannon, Lisa S. Robison, Abigail E. Salinero, Charly Abi-Ghanem, Febronia M. Mansour, Richard D. Kelly, Alvira Tyagi, Rebekah R. Brawley, Jordan D. Ogg and Kristen L. Zuloaga
    Citation: Journal of Neuroinflammation 2022 19:110
  4. The mechanisms by which glia respond to viral central nervous system (CNS) pathogens are now becoming apparent with the demonstration that microglia and astrocytes express an array of pattern recognition recep...

    Authors: Austin M. Jeffries, Alexander J. Suptela and Ian Marriott
    Citation: Journal of Neuroinflammation 2022 19:109
  5. The mechanism by which adamantinomatous craniopharyngioma (ACP) damages the hypothalamus is still unclear. Cyst fluid rich in lipids and inflammatory factors is a characteristic pathological manifestation of A...

    Authors: Yilamujiang Ainiwan, Yiguang Chen, Chaofu Mao, Junxiang Peng, Siyuan Chen, Songtao Wei, Songtao Qi and Jun Pan
    Citation: Journal of Neuroinflammation 2022 19:108
  6. Parkinson’s disease (PD) is the second most frequent neurodegenerative disease. PD etiopathogenesis is multifactorial and not yet fully known, however, the scientific world advised the establishment of neuroin...

    Authors: Alessio Ardizzone, Valentina Bova, Giovanna Casili, Alessia Filippone, Michela Campolo, Marika Lanza, Emanuela Esposito and Irene Paterniti
    Citation: Journal of Neuroinflammation 2022 19:107
  7. This study investigated the relationships of neutrophil count (NC), neutrophil-to-lymphocyte ratio (NLR) and systemic immune-inflammation index (SII) with cerebral small vessel disease (CSVD).

    Authors: Lingling Jiang, Xueli Cai, Dongxiao Yao, Jing Jing, Lerong Mei, Yingying Yang, Shan Li, Aoming Jin, Xia Meng, Hao Li, Tiemin Wei, Yongjun Wang, Yuesong Pan and Yilong Wang
    Citation: Journal of Neuroinflammation 2022 19:106
  8. The important contribution of glia to mechanisms of injury and repair of the nervous system is increasingly recognized. In stark contrast to the central nervous system (CNS), the peripheral nervous system (PNS...

    Authors: Amanda Brosius Lutz, Tawaun A. Lucas, Glenn A. Carson, Christine Caneda, Lu Zhou, Ben A. Barres, Marion S. Buckwalter and Steven A. Sloan
    Citation: Journal of Neuroinflammation 2022 19:105
  9. Metabolic syndrome (MS) is defined as a low-grade proinflammatory state in which abnormal metabolic and cardiovascular factors increase the risk of developing cardiovascular disease and neuroinflammation. Even...

    Authors: Nathalie Obadia, Giulia Andrade, Marina Leardini-Tristão, Letícia Albuquerque, Celina Garcia, Flavia Lima, Júlio Daleprane, Hugo C. Castro-Faria-Neto, Eduardo Tibiriçá and Vanessa Estato
    Citation: Journal of Neuroinflammation 2022 19:104
  10. c-Met, a tyrosine kinase receptor, is the unique receptor for hepatocyte growth factor (HGF). The HGF/c-Met axis is reported to modulate cell migration, maturation, cytokine production, and antigen presentatio...

    Authors: Mahdia Benkhoucha, Ngoc Lan Tran, Gautier Breville, Isis Senoner, Paul F. Bradfield, Thalia Papayannopoulou, Doron Merkler, Thomas Korn and Patrice H. Lalive
    Citation: Journal of Neuroinflammation 2022 19:103
  11. Spinal cord injury (SCI) elicits a robust neuroinflammatory reaction which, in turn, exacerbates the initial mechanical damage. Pivotal players orchestrating this response are macrophages (Mφs) and microglia. ...

    Authors: Jana Van Broeckhoven, Céline Erens, Daniela Sommer, Elle Scheijen, Selien Sanchez, Pia M. Vidal, Dearbhaile Dooley, Elise Van Breedam, Alessandra Quarta, Peter Ponsaerts, Sven Hendrix and Stefanie Lemmens
    Citation: Journal of Neuroinflammation 2022 19:102
  12. Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Sepsis causes cerebral dysfunction in the short and long term and induces disruption of the blood–brain barri...

    Authors: Nobufumi Sekino, Magdy Selim and Amjad Shehadah
    Citation: Journal of Neuroinflammation 2022 19:101
  13. Zika virus (ZIKV) is an emerging flavivirus of global concern. ZIKV infection of the central nervous system has been linked to a variety of clinical syndromes, including microcephaly in fetuses and rare but se...

    Authors: Po-Lun Kung, Tsui-Wen Chou, Marissa Lindman, Nydia P. Chang, Irving Estevez, Benjamin D. Buckley, Colm Atkins and Brian P. Daniels
    Citation: Journal of Neuroinflammation 2022 19:100
  14. Alzheimer’s disease (AD) is a progressive neurodegenerative disease that impacts nearly 400 million people worldwide. The accumulation of amyloid beta (Aβ) in the brain has historically been associated with AD...

    Authors: I. Y. Quiroga, A. E. Cruikshank, M. L. Bond, K. S. M. Reed, B. A. Evangelista, J. H. Tseng, J. V. Ragusa, R. B. Meeker, H. Won, S. Cohen, T. J. Cohen and D. H. Phanstiel
    Citation: Journal of Neuroinflammation 2022 19:99
  15. Neurodegenerative diseases are a group of disorders characterized by progressive loss of certain populations of neurons, which eventually lead to dysfunction. These diseases include Alzheimer’s disease (AD), P...

    Authors: Jiajia Fu, Yan Huang, Ting Bao, Chengcheng Liu, Xi Liu and Xueping Chen
    Citation: Journal of Neuroinflammation 2022 19:98
  16. Macrophages are present in all mammalian tissues and coexist with various cell types in order to respond to different environmental cues. However, the role of these cells has been underestimated in the context...

    Authors: Zeina Msheik, Mohamed El Massry, Amandine Rovini, Fabrice Billet and Alexis Desmoulière
    Citation: Journal of Neuroinflammation 2022 19:97
  17. Elevated production of the cytokines interleukin (IL)-6 or interferon (IFN)-α in the central nervous system (CNS) is implicated in the pathogenesis of neurological diseases such as neuromyelitis optica spectru...

    Authors: Phillip K. West, Andrew N. McCorkindale, Boris Guennewig, Thomas M. Ashhurst, Barney Viengkhou, Emina Hayashida, So Ri Jung, Oleg Butovsky, Iain L. Campbell and Markus J. Hofer
    Citation: Journal of Neuroinflammation 2022 19:96
  18. Excessively deposited fibrotic scar after spinal cord injury (SCI) inhibits axon regeneration. It has been reported that platelet-derived growth factor receptor beta (PDGFRβ), as a marker of fibrotic scar-form...

    Authors: Ziyu Li, Shuisheng Yu, Yanchang Liu, Xuyang Hu, Yiteng Li, Zhaoming Xiao, Yihao Chen, Dasheng Tian, Xinzhong Xu, Li Cheng, Meige Zheng and Juehua Jing
    Citation: Journal of Neuroinflammation 2022 19:95
  19. Development of neurodegeneration in older people has been associated with microglial cell activation triggered by systemic infection. We hypothesize that α7 nicotinic acetylcholine receptor (α7nAChR) plays an ...

    Authors: Inge C. M. Hoogland, Jutka Yik, Dunja Westhoff, Joo-Yeon Engelen-Lee, Merche Valls Seron, Wing Kit Man, Judith H. P. M. Houben-Weerts, Michael W. T. Tanck, David J. van Westerloo, Tom van der Poll, Willem A. van Gool and Diederik van de Beek
    Citation: Journal of Neuroinflammation 2022 19:94
  20. Friedreich’s ataxia is a rare hereditary neurodegenerative disease caused by decreased levels of the mitochondrial protein frataxin. Similar to other neurodegenerative pathologies, previous studies suggested t...

    Authors: Andrés Vicente-Acosta, Alfredo Giménez-Cassina, Javier Díaz-Nido and Frida Loria
    Citation: Journal of Neuroinflammation 2022 19:93
  21. Perioperative neurocognitive disorders (PNDs) are common complications observed among surgical patients. Accumulating evidence suggests that neuroinflammation is one of the major contributors to the developmen...

    Authors: Xuwu Xiang, Xiaodong Tang, Yang Yu, Shulan Xie, Lu Liu, ManLi Chen, Rong Zhang, Xianhui Kang, Yueying Zheng, Guang Yang, Shuyuan Gan and Shengmei Zhu
    Citation: Journal of Neuroinflammation 2022 19:92
  22. The mechanisms underlying dysfunction of choroid plexus (ChP) blood–cerebrospinal fluid (CSF) barrier and lymphocyte invasion in neuroinflammatory responses to stroke are not well understood. In this study, we...

    Authors: Jun Wang, Ruijia Liu, Md Nabiul Hasan, Sydney Fischer, Yang Chen, Matt Como, Victoria M. Fiesler, Mohammad Iqbal H. Bhuiyan, Shuying Dong, Eric Li, Kristopher T. Kahle, Jinwei Zhang, Xianming Deng, Arohan R. Subramanya, Gulnaz Begum, Yan Yin…
    Citation: Journal of Neuroinflammation 2022 19:91
  23. Corneal immune cells interact with corneal sensory nerves during both homeostasis and inflammation. This study sought to evaluate temporal changes to corneal immune cell density in a mouse model of epithelial ...

    Authors: Mengliang Wu, Laura E. Downie, Lisa J. Hill and Holly R. Chinnery
    Citation: Journal of Neuroinflammation 2022 19:90
  24. Myasthenic crisis (MC) and disease exacerbation in myasthenia gravis (MG) are associated with significant lethality and continue to impose a high disease burden on affected patients. Therefore, we sought to de...

    Authors: Christopher Nelke, Frauke Stascheit, Carmen Eckert, Marc Pawlitzki, Christina B. Schroeter, Niklas Huntemann, Philipp Mergenthaler, Ercan Arat, Menekse Öztürk, Dirk Foell, Stefanie Schreiber, Stefan Vielhaber, Asmae Gassa, Henning Stetefeld, Michael Schroeter, Benjamin Berger…
    Citation: Journal of Neuroinflammation 2022 19:89
  25. Soluble triggering receptor expressed on myeloid cells 2 (sTREM2), which reflects microglia activation, has been reported closely associated with neuronal injury and neuroinflammation. We aimed to prospectivel...

    Authors: Yaling Lu, Yu Zhao, Qi Zhang, Chongquan Fang, Anran Bao, Wenjing Dong, Yanbo Peng, Hao Peng, Zhong Ju, Jiang He, Yonghong Zhang, Tan Xu and Chongke Zhong
    Citation: Journal of Neuroinflammation 2022 19:88
  26. Chronic morphine exposure induces immunosuppression in the peripheral and central nervous system, resulting in susceptibility of patients to invading pathogens. Mitophagy is a crucial regulator of inflammation...

    Authors: Jialing Peng, Jingrui Pan, Hongxuan Wang, Jingjing Mo, Lihuan Lan and Ying Peng
    Citation: Journal of Neuroinflammation 2022 19:87
  27. Despite rigorous confirmation with reliable assays, some individuals showing the neuromyelitis optica spectrum disorder (NMOSD) phenotype remain negative for both aquaporin-4 (AQP4) and myelin oligodendrocyte ...

    Authors: Jae-Won Hyun, Yeseul Kim, Ki Hoon Kim, Su-Hyun Kim, Mads Nikolaj Olesen, Nasrin Asgari, Sasitorn Siritho, Friedemann Paul and Ho Jin Kim
    Citation: Journal of Neuroinflammation 2022 19:86
  28. Angiostrongylus cantonensis is also known as rat lungworm. Infection with this parasite is a zoonosis that can cause eosinophilic meningitis and/or eosinophilic meningoencephalitis in humans and may lead to fatal...

    Authors: Kai-Yuan Jhan, Pi-Kai Chang, Chien-Ju Cheng, Shih-Ming Jung and Lian-Chen Wang
    Citation: Journal of Neuroinflammation 2022 19:85
  29. miR-203 was first indicated in maintaining skin homeostasis and innate immunity. Aberrant expression of miR-203 was found associated with pathological progressions of immune disorders, cancers, as well as neur...

    Authors: Shufang Li, Linpeng Li, Jieli Li, Xiaosheng Liang, Chao Song and Yi Zou
    Citation: Journal of Neuroinflammation 2022 19:84
  30. Ischemic stroke is a medical emergency that primarily affects the elderly. A complex immune response in the post-stroke brain constitutes a key component of stroke pathophysiology. This study aimed to determin...

    Authors: Xuan Li, Jingjun Lyu, Ran Li, Vaibhav Jain, Yuntian Shen, Ángela del Águila, Ulrike Hoffmann, Huaxin Sheng and Wei Yang
    Citation: Journal of Neuroinflammation 2022 19:83
  31. Neuroinflammation is a crucial factor in the development of secondary brain injury after intracerebral hemorrhage (ICH). Irisin is a newly identified myokine that confers strong neuroprotective effects in expe...

    Authors: Yao Wang, Mi Tian, Jiaying Tan, Xu Pei, Chaocheng Lu, Yuewen Xin, Shuixiang Deng, Feng Zhao, Yanqin Gao and Ye Gong
    Citation: Journal of Neuroinflammation 2022 19:82
  32. Microglia participate in the immune response upon central nervous system (CNS) infections. However, the role of these cells during herpes simplex encephalitis (HSE) has not been fully characterized. We sought ...

    Authors: Olus Uyar, Juan Manuel Dominguez, Maude Bordeleau, Lina Lapeyre, Fernando González Ibáñez, Luc Vallières, Marie-Eve Tremblay, Jacques Corbeil and Guy Boivin
    Citation: Journal of Neuroinflammation 2022 19:81
  33. Neuroinflammation in spinal dorsal horn (SDH) plays an important role in the pathogenesis of interstitial cystitis/bladder pain syndrome (IC/BPS). Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs)...

    Authors: Chi Zhang, Yong Huang, Fubing Ouyang, Minzhi Su, Wenbiao Li, Jialiang Chen, Hengjun Xiao, Xiangfu Zhou and Bolong Liu
    Citation: Journal of Neuroinflammation 2022 19:80
  34. Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) in cerebrospinal fluid (CSF) has been described as a biomarker for microglial activation, which were observed increased in a variety of neurolo...

    Authors: Ming-Hao Dong, Luo-Qi Zhou, Yue Tang, Man Chen, Jun Xiao, Ke Shang, Gang Deng, Chuan Qin and Dai-Shi Tian
    Citation: Journal of Neuroinflammation 2022 19:79
  35. Macular subretinal fibrosis is the end-stage complication of neovascular age-related macular degeneration (nAMD). We previously developed a mouse model of two-stage laser-induced subretinal fibrosis that mimic...

    Authors: Caijiao Yi, Jian Liu, Wen Deng, Chang Luo, Jinyan Qi, Mei Chen and Heping Xu
    Citation: Journal of Neuroinflammation 2022 19:78
  36. Cognitive impairment is one of the primary sequelae affecting the quality of life of patients with Japanese encephalitis (JE). The clinical treatment is mainly focused on life support, lacking of targeted trea...

    Authors: Rong Yin, Linpeng Yang, Ying Hao, Zhiqi Yang, Tao Lu, Wanjun Jin, Meiling Dan, Liang Peng, Yingjie Zhang, Yaxuan Wei, Rong Li, Huiping Ma, Yuanyuan Shi and Pengcheng Fan
    Citation: Journal of Neuroinflammation 2022 19:77
  37. Poststroke cognitive impairment (PSCI) is prevalent in stroke patients. The etiology of PSCI remains largely unknown. We previously found that stroke induces gut microbiota dysbiosis which affects brain injury...

    Authors: Huidi Wang, Mingsi Zhang, Jie Li, Jianhai Liang, Mengjia Yang, Genghong Xia, Yueran Ren, Hongwei Zhou, Qiheng Wu, Yan He and Jia Yin
    Citation: Journal of Neuroinflammation 2022 19:76
  38. Ketamine, a multimodal dissociative anesthetic drug, is widely used as an analgesic following traumatic injury. Although ketamine may produce anti-inflammatory effects when administered after injury, the immun...

    Authors: Haley F. Spencer, Rina Y. Berman, Martin Boese, Michael Zhang, Sharon Y. Kim, Kennett D. Radford and Kwang H. Choi
    Citation: Journal of Neuroinflammation 2022 19:75
  39. We recently reported increased levels of neutrophils, monocytes and C-reactive protein (CRP) correlated with symptom severity in acute schizophrenia. Here, we investigated if a similar pattern of innate immune...

    Authors: Deepti Singh, Paul C. Guest, Henrik Dobrowolny, Veronika Vasilevska, Gabriela Meyer-Lotz, Hans-Gert Bernstein, Katrin Borucki, Alexandra Neyazi, Bernhard Bogerts, Roland Jacobs and Johann Steiner
    Citation: Journal of Neuroinflammation 2022 19:74
  40. Behavioral comorbidities, such as anxiety and depression, are a prominent feature of IBD. The signals from the inflamed gut that cause changes in the brain leading to these behavioral comorbidities remain to b...

    Authors: Nina L. Cluny, Kewir D. Nyuyki, Wagdi Almishri, Lateece Griffin, Benjamin H. Lee, Simon A. Hirota, Quentin J. Pittman, Mark G. Swain and Keith A. Sharkey
    Citation: Journal of Neuroinflammation 2022 19:73
  41. Cigarette smoking (CS) is the leading cause of chronic obstructive pulmonary disease (COPD). The “spill-over” of pulmonary inflammation into the systemic circulation may damage the brain, leading to cognitive ...

    Authors: Simone N. De Luca, Kurt Brassington, Stanley M. H. Chan, Aleksandar Dobric, Kevin Mou, Huei Jiunn Seow and Ross Vlahos
    Citation: Journal of Neuroinflammation 2022 19:72
  42. After traumatic brain injury (TBI), an acute, robust inflammatory cascade occurs that is characterized by the activation of resident cells such as microglia, the migration and recruitment of peripheral immune ...

    Authors: Jian Hu, Xue Wang, Xiongjian Chen, Yani Fang, Kun Chen, Wenshuo Peng, Zhengyi Wang, Kaiming Guo, Xianxi Tan, Fei Liang, Li Lin and Ye Xiong
    Citation: Journal of Neuroinflammation 2022 19:71
  43. The etiology of Rasmussen's encephalitis (RE), a rare chronic neurological disorder characterized by CD8+ T cell infiltration and unihemispheric brain atrophy, is still unknown. Various human herpes viruses (H...

    Authors: Yi-Song Wang, Dong Liu, Xin Wang, Qiao-Li Luo, Ling Ding, Dong-Ying Fan, Qi-Liang Cai, Chong-Yang Tang, Wei Yang, Yu-Guang Guan, Tian-Fu Li, Pei-Gang Wang, Guo-Ming Luan and Jing An
    Citation: Journal of Neuroinflammation 2022 19:70
  44. Nod-like receptors (NLRs) are critical to innate immune activation and induction of adaptive T cell responses. Yet, their role in autoinflammatory diseases of the central nervous system (CNS) remains incomplet...

    Authors: Ellen J. Lee, Ruth J. Napier, Emily E. Vance, Sydney J. Lashley, Agnieszka D. Truax, Jenny P. Ting and Holly L. Rosenzweig
    Citation: Journal of Neuroinflammation 2022 19:69
  45. Peripheral nerve injuries are accompanied by inflammatory reactions, over-activation of which may hinder recovery. Among pro-inflammatory pathways, inflammasomes are one of the most potent, leading to release ...

    Authors: Kinga Molnár, Bernát Nógrádi, Rebeka Kristóf, Ádám Mészáros, Krisztián Pajer, László Siklós, Antal Nógrádi, Imola Wilhelm and István A. Krizbai
    Citation: Journal of Neuroinflammation 2022 19:68
  46. Inflammation induced by intracerebral hemorrhage (ICH) is one of the main causes of the high mortality and poor prognosis of patients with ICH. A1 astrocytes are closely associated with neuroinflammation and n...

    Authors: Xiaowei Fei, Ya-nan Dou, Li Wang, Xiuquan Wu, Yu Huan, Shuang Wu, Xin He, Weihao Lv, Jialiang Wei and Zhou Fei
    Citation: Journal of Neuroinflammation 2022 19:67
  47. Herpes simplex virus 1 (HSV-1) can induce fatal encephalitis. Cellular factors regulate the host immunity to affect the severity of HSV-1 encephalitis. Recent reports focus on the significance of thrombomoduli...

    Authors: Meng-Shan Tsai, Li-Chiu Wang, Hua-Lin Wu, Shun-Fen Tzeng, Edward M. Conway, Sheng-Min Hsu and Shun-Hua Chen
    Citation: Journal of Neuroinflammation 2022 19:66
  48. Membrane-type matrix metalloproteinase 5 (MT5-MMP) deficiency in the 5xFAD mouse model of Alzheimer's disease (AD) reduces brain neuroinflammation and amyloidosis, and prevents deficits in synaptic activity an...

    Authors: Dominika Pilat, Jean-Michel Paumier, Laura García-González, Laurence Louis, Delphine Stephan, Christine Manrique, Michel Khrestchatisky, Eric Di Pasquale, Kévin Baranger and Santiago Rivera
    Citation: Journal of Neuroinflammation 2022 19:65
  49. Postoperative cognitive dysfunction (POCD) is a common complication following anesthesia and surgery. General anesthetic isoflurane has potential neurotoxicity and induces cognitive impairments, but the exact ...

    Authors: Rui Dong, Yuqiang Han, Linhao Jiang, Shuai Liu, Fujun Zhang, Liangyu Peng, Zimo Wang, Zhengliang Ma, Tianjiao Xia and Xiaoping Gu
    Citation: Journal of Neuroinflammation 2022 19:64
  50. Vacuolar sorting protein 35 (VPS35), a key component of the retromer, plays an essential role in selectively retrieval of transmembrane proteins from endosomes to trans-Golgi networks. Dysfunctional retromer i...

    Authors: Xiao Ren, Lingling Yao, YongGang Wang, Lin Mei and Wen-Cheng Xiong
    Citation: Journal of Neuroinflammation 2022 19:61

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