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  1. Inflammatory bowel disease (IBD), which mainly includes ulcerative colitis (UC) and Crohn's disease (CD), is a group of chronic bowel diseases that are characterized by abdominal pain, diarrhea, and bloody sto...

    Authors: Li-Ming Chen, Chun-Hui Bao, Yu Wu, Shi-Hua Liang, Di Wang, Lu-Yi Wu, Yan Huang, Hui-Rong Liu and Huan-Gan Wu

    Citation: Journal of Neuroinflammation 2021 18:135

    Content type: Review

    Published on:

  2. Traumatic brain injury (TBI) remains one of the leading causes of death and disability worldwide; more than 10 million people are hospitalized for TBI every year around the globe. While the primary injury rema...

    Authors: Zhimin Zou, Li Li, Nadine Schäfer, Qiaobing Huang, Marc Maegele and Zhengtao Gu

    Citation: Journal of Neuroinflammation 2021 18:134

    Content type: Review

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  3. Brain ischemia compromises natural killer (NK) cell-mediated immune defenses by acting on neurogenic and intracellular pathways. Less is known about the posttranscriptional mechanisms that regulate NK cell act...

    Authors: Yan Feng, Yan Li, Ying Zhang, Bo-Hao Zhang, Hui Zhao, Xin Zhao, Fu-Dong Shi, Wei-Na Jin and Xiao-An Zhang

    Citation: Journal of Neuroinflammation 2021 18:133

    Content type: Research

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  4. An increasing number of studies evidences that amyotrophic lateral sclerosis (ALS) is characterized by extensive alterations in different cell types and in different regions besides the CNS. We previously repo...

    Authors: Martina Milani, Eleonora Mammarella, Simona Rossi, Chiara Miele, Serena Lattante, Mario Sabatelli, Mauro Cozzolino, Nadia D’Ambrosi and Savina Apolloni

    Citation: Journal of Neuroinflammation 2021 18:132

    Content type: Research

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  5. Tau pathology is a hallmark of Alzheimer’s disease (AD) and other tauopathies. During disease progression, abnormally phosphorylated forms of tau aggregate and accumulate into neurofibrillary tangles, leading ...

    Authors: Xiao-ying Sun, Ling-jie Li, Quan-Xiu Dong, Jie Zhu, Ya-ru Huang, Sheng-jie Hou, Xiao-lin Yu and Rui-tian Liu

    Citation: Journal of Neuroinflammation 2021 18:131

    Content type: Research

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  6. Astrocytes are the predominant glial cell type in the central nervous system (CNS) that can secrete various cytokines and chemokines mediating neuropathology in response to danger signals. D-dopachrome tautome...

    Authors: Huiyuan Ji, Yuxin Zhang, Chen Chen, Hui Li, Bingqiang He, Ting Yang, Chunshuai Sun, Huifei Hao, Xingyuan Zhang, Yingjie Wang, Yue Zhou, Zhenjie Zhu, Yuming Hu, Aihong Li, Aisong Guo and Yongjun Wang

    Citation: Journal of Neuroinflammation 2021 18:130

    Content type: Research

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  7. Microglial activation-mediated neuroinflammation plays an important role in the progression of neurodegenerative diseases. Inflammatory activation of microglial cells is often accompanied by a metabolic switch...

    Authors: Junjie Cheng, Rong Zhang, Zhirou Xu, Youliang Ke, Renjuan Sun, Huicui Yang, Xiaohu Zhang, Xuechu Zhen and Long-Tai Zheng

    Citation: Journal of Neuroinflammation 2021 18:129

    Content type: Research

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  8. Patients with prior illness are more vulnerable to heat stroke-induced injury, but the underlying mechanism is unknown. Recent studies suggested that NLRP3 inflammasome played an important role in the pathophy...

    Authors: Zi-Teng Zhang, Xiao-Lei Gu, Xin Zhao, Xian He, Hao-Wei Shi, Kun Zhang, Yi-Ming Zhang, Yi-Nan Su, Jiang-Bo Zhu, Zhi-Wei Li and Guo-Bao Li

    Citation: Journal of Neuroinflammation 2021 18:128

    Content type: Research

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  9. Stroke produces a powerful inflammatory cascade in the brain, but also a suppression of the peripheral immune system, which is also called stroke-induced immunosuppression (SIIS). The main processes that lead ...

    Authors: Júlia Faura, Alejandro Bustamante, Francesc Miró-Mur and Joan Montaner

    Citation: Journal of Neuroinflammation 2021 18:127

    Content type: Review

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  10. Brain astroglia are activated preceding the onset of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). We characterized the effects of brain astroglia on spinal cord ...

    Authors: Hayato Une, Ryo Yamasaki, Satoshi Nagata, Hiroo Yamaguchi, Yuko Nakamuta, Ulfa Camelia Indiasari, Yiwen Cui, Koji Shinoda, Katsuhisa Masaki, Magdalena Götz and Jun-ichi Kira

    Citation: Journal of Neuroinflammation 2021 18:126

    Content type: Research

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  11. A key factor in the development of viral encephalitis is a virus crossing the blood-brain barrier (BBB). We have previously shown that age-related susceptibility of mice to the La Crosse virus (LACV), the lead...

    Authors: Rahul Basu, Vinod Nair, Clayton W. Winkler, Tyson A. Woods, Iain D. C. Fraser and Karin E. Peterson

    Citation: Journal of Neuroinflammation 2021 18:125

    Content type: Research

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  12. Alzheimer’s disease (AD) and Parkinson’s disease (PD) are characterized by brain accumulation of aggregated amyloid-beta (Aβ) and alpha-synuclein (αSYN), respectively. In order to develop effective therapies, ...

    Authors: Jinar Rostami, Tobias Mothes, Mahshad Kolahdouzan, Olle Eriksson, Mohsen Moslem, Joakim Bergström, Martin Ingelsson, Paul O’Callaghan, Luke M. Healy, Anna Falk and Anna Erlandsson

    Citation: Journal of Neuroinflammation 2021 18:124

    Content type: Research

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  13. The nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family pyrin domain-containing 3 (NLRP3) inflammasome is a member of the NLR family of inherent immune cell sensors. The NLRP3 inflammaso...

    Authors: Qingxue Xu, Bo Zhao, Yingze Ye, Yina Li, Yonggang Zhang, Xiaoxing Xiong and Lijuan Gu

    Citation: Journal of Neuroinflammation 2021 18:123

    Content type: Review

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  14. Stroke affects 3–4% of adults and kills numerous people each year. Recovering blood flow with minimal reperfusion-induced injury is crucial. However, the mechanisms underlying reperfusion-induced injury, parti...

    Authors: Feng Zhou, Yu-Kai Wang, Cheng-Guo Zhang and Bing-Yi Wu

    Citation: Journal of Neuroinflammation 2021 18:122

    Content type: Research

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  15. To investigate age-related severity, patterns of retinal structural damage, and functional visual recovery in pediatric and adult cohorts of myelin oligodendrocyte glycoprotein antibody-associated disease (MOG...

    Authors: Joachim Havla, Thivya Pakeerathan, Carolin Schwake, Jeffrey L. Bennett, Ingo Kleiter, Ana Felipe-Rucián, Stephanie C. Joachim, Amelie S. Lotz-Havla, Tania Kümpfel, Markus Krumbholz, Eva M. Wendel, Markus Reindl, Charlotte Thiels, Thomas Lücke, Kerstin Hellwig, Ralf Gold…

    Citation: Journal of Neuroinflammation 2021 18:121

    Content type: Research

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  16. Authors: Luis A. Rojas-Colón, Pramod K. Dash, Fabiola A. Morales-Vías, Madeline Lebrón-Dávila, Pedro A. Ferchmin, John B. Redell, Geronimo Maldonado-Martínez and Wanda I. Vélez-Torres

    Citation: Journal of Neuroinflammation 2021 18:120

    Content type: Correction

    Published on:

    The original article was published in Journal of Neuroinflammation 2021 18:95

  17. Cerebral ischemia–reperfusion (I/R) injury is a major cause of early complications and unfavorable outcomes after endovascular thrombectomy (EVT) therapy in patients with acute ischemic stroke (AIS). Recent st...

    Authors: Xin Xu, Weiwei Gao, Lei Li, Jiheng Hao, Bin Yang, Tao Wang, Long Li, Xuesong Bai, Fanjian Li, Honglei Ren, Meng Zhang, Liyong Zhang, Jiyue Wang, Dong Wang, Jianning Zhang and Liqun Jiao

    Citation: Journal of Neuroinflammation 2021 18:119

    Content type: Research

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  18. Translational failures in anti-adhesion molecule therapies after stroke reveal the necessity of developing new strategies that not only interrupt leukocyte recruitment but also consider the inhibition of endot...

    Authors: Ceshu Gao, Wangyue Jia, Wendeng Xu, Qiong Wu and Jian Wu

    Citation: Journal of Neuroinflammation 2021 18:118

    Content type: Research

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  19. Calcitonin gene-related peptide (CGRP) as a mediator of microglial activation at the transcriptional level may facilitate nociceptive signaling. Trimethylation of H3 lysine 27 (H3K27me3) by enhancer of zeste h...

    Authors: Qi An, Chenyan Sun, Ruidi Li, Shuhui Chen, Xinpei Gu, Shuhong An and Zhaojin Wang

    Citation: Journal of Neuroinflammation 2021 18:117

    Content type: Research

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  20. Neuroinflammation is an underlying pathology of all neurological conditions, the understanding of which is still being comprehended. A specific molecular pathway that has been overlooked in neuroinflammation i...

    Authors: Ana Lúcia Rebelo, Francesco Gubinelli, Pauline Roost, Caroline Jan, Emmanuel Brouillet, Nadja Van Camp, Richard R. Drake, Radka Saldova and Abhay Pandit

    Citation: Journal of Neuroinflammation 2021 18:116

    Content type: Research

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  21. Mood and metabolic disorders are interrelated and may share common pathological processes. Autonomic neurons link the brain with the gastrointestinal tract and constitute a likely pathway for peripheral metabo...

    Authors: Luisa Seguella, Mirella Pesce, Riccardo Capuano, Fabrizio Casano, Marcella Pesce, Chiara Corpetti, Martina Vincenzi, Daniela Maftei, Roberta Lattanzi, Alessandro Del Re, Giovanni Sarnelli, Brian D. Gulbransen and Giuseppe Esposito

    Citation: Journal of Neuroinflammation 2021 18:115

    Content type: Research

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  22. Escherichia coli is the most common Gram-negative bacterium causing meningitis, and E. coli meningitis is associated with high mortality and morbidity throughout the world. Our previous study showed that E. coli ...

    Authors: Bo Yang, Ruicheng Yang, Bojie Xu, Jiyang Fu, Xinyi Qu, Liang Li, Menghong Dai, Chen Tan, Huanchun Chen and Xiangru Wang

    Citation: Journal of Neuroinflammation 2021 18:114

    Content type: Research

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  23. Sex and age are emerging as influential variables that affect spinal cord injury (SCI) recovery. Despite a changing demographic towards older age at the time of SCI, the effects of sex or age on inflammation r...

    Authors: Andrew N. Stewart, John L. Lowe, Ethan P. Glaser, Caitlin A. Mott, Ryan K. Shahidehpour, Katelyn E. McFarlane, William M. Bailey, Bei Zhang and John C. Gensel

    Citation: Journal of Neuroinflammation 2021 18:113

    Content type: Research

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  24. Accumulating evidence suggests that disease-associated microglia (DAM), a recently discovered subset of microglia, plays a protective role in neurological diseases. Targeting DAM phenotypic transformation may ...

    Authors: Zhicheng Zheng, Peiyu Liang, Baohua Hou, Xin Lu, Qianwen Ma, Xiaomin Yu, Song Han, Biwen Peng, Taoxiang Chen, Wanhong Liu, Jun Yin and Xiaohua He

    Citation: Journal of Neuroinflammation 2021 18:112

    Content type: Research

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  25. Dry eye disease (DED) is a multifactorial disease of the ocular surface accompanied by neurosensory abnormalities. Here, we evaluated the effectiveness of transient receptor potential vanilloid-1 (TRPV1) block...

    Authors: Darine Fakih, Adrian Guerrero-Moreno, Christophe Baudouin, Annabelle Réaux-Le Goazigo and Stéphane Mélik Parsadaniantz

    Citation: Journal of Neuroinflammation 2021 18:111

    Content type: Research

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  26. Multiple sclerosis (MS) is a progressive autoimmune disease characterized by the accumulation of pathogenic inflammatory immune cells in the central nervous system (CNS) that subsequently causes focal inflamma...

    Authors: Wen-Tsan Weng, Ping-Chang Kuo, Dennis A. Brown, Barbara A. Scofield, Destin Furnas, Hallel C. Paraiso, Pei-Yu Wang, I-Chen Yu and Jui-Hung Yen

    Citation: Journal of Neuroinflammation 2021 18:110

    Content type: Research

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  27. Emergent large vessel occlusion (ELVO) strokes are devastating ischemic vascular events for which novel treatment options are needed. Using vascular cell adhesion molecule 1 (VCAM1) as a prototype, the objecti...

    Authors: Benton Maglinger, Madison Sands, Jacqueline A. Frank, Christopher J. McLouth, Amanda L. Trout, Jill M. Roberts, Stephen Grupke, Jadwiga Turchan-Cholewo, Ann M. Stowe, Justin F. Fraser and Keith R. Pennypacker

    Citation: Journal of Neuroinflammation 2021 18:109

    Content type: Research

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  28. Interleukin 9 (IL-9), produced mainly by T helper 9 (Th9) cells, has been recognized as an important regulator in multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). ...

    Authors: Xiaomei Liu, Feng Zhou, Weixiao Wang, Guofang Chen, Qingxiu Zhang, Ruixue Lv, Zijun Zhao, Xiangyang Li, Qian Yu, Jessica M. Meves, Hui Hua, Xiaocui Li, Xiaotian Wang, Hong Sun and Dianshuai Gao

    Citation: Journal of Neuroinflammation 2021 18:108

    Content type: Research

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  29. Tuberous sclerosis complex 1 (Tsc1) is known to regulate the development and function of various cell types, and RORγt is a critical transcription factor in the immune system. However, whether Tsc1 participates i...

    Authors: Yafei Deng, Qinglan Yang, Yao Yang, Yana Li, Hongyan Peng, Shuting Wu, Shuju Zhang, Baige Yao, Shuhui Li, Yuan Gao, Xiaohui Li, Liping Li and Youcai Deng

    Citation: Journal of Neuroinflammation 2021 18:107

    Content type: Research

    Published on:

  30. Nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2)-induced oxidative stress, including the production of reactive oxygen species (ROS) and hydrogen peroxide, plays a pivotal role in neuropathic pain....

    Authors: Jing Xu, Shinan Wu, Junfei Wang, Jianmei Wang, Yi Yan, Mengye Zhu, Daying Zhang, Changyu Jiang and Tao Liu

    Citation: Journal of Neuroinflammation 2021 18:106

    Content type: Research

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  31. Neuromyelitis optica spectrum disorder (NMOSD) is a frequently disabling neuroinflammatory syndrome with a relapsing course. Blood-based disease severity and prognostic biomarkers for NMOSD are a yet unmet cli...

    Authors: Patrick Schindler, Ulrike Grittner, Johanna Oechtering, David Leppert, Nadja Siebert, Ankelien S. Duchow, Frederike C. Oertel, Susanna Asseyer, Joseph Kuchling, Hanna G. Zimmermann, Alexander U. Brandt, Pascal Benkert, Markus Reindl, Sven Jarius, Friedemann Paul, Judith Bellmann-Strobl…

    Citation: Journal of Neuroinflammation 2021 18:105

    Content type: Research

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  32. Cell transplantation-based treatments for neurological disease are promising, yet graft rejection remains a major barrier to successful regenerative therapies. Our group and others have shown that long-lasting...

    Authors: Rui Wang, Chengyan Chu, Zhiliang Wei, Lin Chen, Jiadi Xu, Yajie Liang, Miroslaw Janowski, Robert D. Stevens and Piotr Walczak

    Citation: Journal of Neuroinflammation 2021 18:104

    Content type: Research

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  33. Our understanding of the relationship between plasma and cerebrospinal fluid (CSF) remains limited, which poses an obstacle to the identification of blood-based markers of neuroinflammatory disorders. To bette...

    Authors: Sarinnapha M. Vasunilashorn, Long H. Ngo, Simon T. Dillon, Tamara G. Fong, Becky C. Carlyle, Pia Kivisäkk, Bianca A. Trombetta, Kamen V. Vlassakov, Lisa J. Kunze, Steven E. Arnold, Zhongcong Xie, Sharon K. Inouye, Towia A. Libermann and Edward R. Marcantonio

    Citation: Journal of Neuroinflammation 2021 18:103

    Content type: Research

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  34. Autism spectrum disorder (ASD) is characterized as a neurodevelopmental disorder, and one of the main hypotheses regarding its cause is genetic factors. A previous meta-analysis of seven microarray studies and...

    Authors: Fumie Horiuchi, Yuta Yoshino, Hiroshi Kumon, Rie Hosokawa, Kiwamu Nakachi, Kentaro Kawabe, Jun-ichi Iga and Shu-ichi Ueno

    Citation: Journal of Neuroinflammation 2021 18:102

    Content type: Research

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  35. Interleukin 23 is a critical cytokine in the pathogenesis of multiple sclerosis. But the local impact of interleukin 23 on the course of neuroinflammation is still not well defined. To further characterize the...

    Authors: Louisa Nitsch, Simon Petzinna, Julian Zimmermann, Linda Schneider, Marius Krauthausen, Michael T. Heneka, Daniel R. Getts, Albert Becker and Marcus Müller

    Citation: Journal of Neuroinflammation 2021 18:101

    Content type: Research

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  36. Microglia are resident innate immune cells in the brain, and activation of these myeloid cells results in secretion of a variety of pro-inflammatory molecules, leading to the development of neurodegenerative d...

    Authors: Jingdong Zhang, Michael Boska, Ya Zheng, Jianuo Liu, Howard S. Fox and Huangui Xiong

    Citation: Journal of Neuroinflammation 2021 18:100

    Content type: Research

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  37. The α7 nicotinic acetylcholine receptor (α7 nAChR) negatively regulates the synthesis and release of pro-inflammatory cytokines by immune cells. Our previous studies showed that in encephalitogenic T cells, α7...

    Authors: Tehila Mizrachi, Oshrit Marsha, Karen Brusin, Yael Ben-David, Ganesh A. Thakur, Adi Vaknin-Dembinsky, Millet Treinin and Talma Brenner

    Citation: Journal of Neuroinflammation 2021 18:99

    Content type: Research

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  38. Multiple sclerosis (MS) is a debilitating neurological disease caused by autoimmune destruction of the myelin sheath. Experimental autoimmune encephalomyelitis (EAE) is a widely used animal model for the patho...

    Authors: Junjie Zhao, Yun Liao, William Miller-Little, Jianxing Xiao, Caini Liu, Xiaoxia Li, Xiao Li and Zizhen Kang

    Citation: Journal of Neuroinflammation 2021 18:98

    Content type: Research

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  39. Our previous study indicated that hypoxic preconditioning reduced receptor interacting protein (RIP) 3-mediated necroptotic neuronal death in hippocampal CA1 of adult rats after transient global cerebral ische...

    Authors: Lixuan Zhan, Xiaomei Lu, Wensheng Xu, Weiwen Sun and En Xu

    Citation: Journal of Neuroinflammation 2021 18:97

    Content type: Research

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  40. Postherpetic neuralgia (PHN) is a devastating complication after varicella-zoster virus infection. Brain-derived neurotrophic factor (BDNF) has been shown to participate in the pathogenesis of PHN. A truncated...

    Authors: Xiang Wei, Lina Wang, Jie Hua, Xiao-hong Jin, Fuhai Ji, Ke Peng, Bin Zhou, Jianping Yang and Xiao-wen Meng

    Citation: Journal of Neuroinflammation 2021 18:96

    Content type: Research

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  41. Chronic brain inflammation has been implicated in the pathogenesis of various neurodegenerative diseases and disorders. For example, overexpression of pro-inflammatory cytokines has been associated with impair...

    Authors: Luis A. Rojas-Colón, Pramod K. Dash, Fabiola A. Morales-Vías, Madeline Lebrón-Dávila, Pedro A. Ferchmin, John B. Redell, Geronimo Maldonado-Martínez and Wanda I. Vélez-Torres

    Citation: Journal of Neuroinflammation 2021 18:95

    Content type: Research

    Published on:

    The Correction to this article has been published in Journal of Neuroinflammation 2021 18:120

  42. Neuroinflammation may contribute to the pathogenesis of Huntington’s disease, given evidence of activated microglia and elevated levels of inflammatory molecules in disease gene carriers, even those many years...

    Authors: Grace C. O’Regan, Sahar H. Farag, Caroline S. Casey, Alison Wood-Kaczmar, Jennifer M. Pocock, Sarah J. Tabrizi and Ralph Andre

    Citation: Journal of Neuroinflammation 2021 18:94

    Content type: Research

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  43. Postoperative pain is a common phenomenon after surgery and is closely associated with the development of postoperative cognitive dysfunction (POCD). Persistent pain and systemic inflammation caused by surgery...

    Authors: Inja Cho, Jeong Min Kim, Eun Jung Kim, So Yeon Kim, Eun Hee Kam, Eunji Cheong, Minah Suh and Bon-Nyeo Koo

    Citation: Journal of Neuroinflammation 2021 18:93

    Content type: Research

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  44. Tumor necrosis factor-α (TNF-α) is a pro-inflammatory cytokine involved in pain processing and hypersensitivity. It regulates not only the expression of a variety of inflammatory mediators but also the functio...

    Authors: Shuang Wei, Chun-Yu Qiu, Ying Jin, Ting-Ting Liu and Wang-Ping Hu

    Citation: Journal of Neuroinflammation 2021 18:92

    Content type: Research

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  45. We previously reported a correlation between small doses of oxaliplatin penetrating onto the spinal cord and acute pain after chemotherapy. Here, we propose that MT2 within the spinal dorsal horns participates...

    Authors: Xuelin Huang, Jie Deng, Ting Xu, Wenjun Xin, Yuehong Zhang and Xiangcai Ruan

    Citation: Journal of Neuroinflammation 2021 18:91

    Content type: Research

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  46. A high-salt diet (HSD) is one of the major risk factors for acute ischemic stroke (AIS). As a potential mechanism, surplus salt intake primes macrophages towards a proinflammatory phenotype. In this study, whe...

    Authors: Mengyan Hu, Yinyao Lin, Xuejiao Men, Shisi Wang, Xiaobo Sun, Qiang Zhu, Danli Lu, Sanxin Liu, Bingjun Zhang, Wei Cai and Zhengqi Lu

    Citation: Journal of Neuroinflammation 2021 18:90

    Content type: Research

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  47. Immune-mediated neuropathies, such as chronic inflammatory demyelinating polyneuropathy (CIDP) are treatable neuropathies. Among individuals with diabetic neuropathy, it remains a challenge to identify those i...

    Authors: Michael Fleischer, Inn Lee, Friedrich Erdlenbruch, Lena Hinrichs, Ioannis N. Petropoulos, Rayaz A. Malik, Hans-Peter Hartung, Bernd C. Kieseier, Christoph Kleinschnitz and Mark Stettner

    Citation: Journal of Neuroinflammation 2021 18:89

    Content type: Research

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  48. It is suggested that neuroinflammation, in which activated microglial cells play a relevant role, contributes to the development of Parkinson’s disease (PD). Consequently, the modulation of microglial activati...

    Authors: Neus Rabaneda-Lombarte, Joan Serratosa, Jordi Bové, Miquel Vila, Josep Saura and Carme Solà

    Citation: Journal of Neuroinflammation 2021 18:88

    Content type: Research

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  49. Subcortical ischemic vascular dementia, one of the major subtypes of vascular dementia, is characterized by lacunar infarcts and white matter lesions caused by chronic cerebral hypoperfusion. In this study, we...

    Authors: Kaoru Suzuki, Mitsuru Shinohara, Yoshihiro Uno, Yoshitaka Tashiro, Ghupurjan Gheni, Miho Yamamoto, Akio Fukumori, Akihiko Shindo, Tomoji Mashimo, Hidekazu Tomimoto and Naoyuki Sato

    Citation: Journal of Neuroinflammation 2021 18:86

    Content type: Research

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