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  1. Research

    Inflammatory demyelination alters subcortical visual circuits

    Multiple sclerosis (MS) is an inflammatory demyelinating disease classically associated with axonal damage and loss; more recently, however, synaptic changes have been recognized as additional contributing fac...

    Sheila Espírito Santo Araújo, Henrique Rocha Mendonça, Natalie A. Wheeler, Paula Campello-Costa, Kimberle M. Jacobs, Flávia C. A. Gomes, Michael A. Fox and Babette Fuss

    Journal of Neuroinflammation 2017 14:162

    Published on: 18 August 2017

  2. Research

    Endogenous hydrogen sulphide attenuates NLRP3 inflammasome-mediated neuroinflammation by suppressing the P2X7 receptor after intracerebral haemorrhage in rats

    Emerging studies have demonstrated the important physiological and pathophysiological roles of hydrogen sulphide (H2S) as a gasotransmitter for NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammas...

    Hengli Zhao, Pengyu Pan, Yang Yang, Hongfei Ge, Weixiang Chen, Jie Qu, Jiantao Shi, Gaoyu Cui, Xin Liu, Hua Feng and Yujie Chen

    Journal of Neuroinflammation 2017 14:163

    Published on: 18 August 2017

  3. Research

    Age exacerbates microglial activation, oxidative stress, inflammatory and NOX2 gene expression, and delays functional recovery in a middle-aged rodent model of spinal cord injury

    Spinal cord injury (SCI) among people over age 40 has been steadily increasing since the 1980s and is associated with worsened outcome than injuries in young people. Age-related increases in reactive oxygen sp...

    Ramona E. von Leden, Guzal Khayrullina, Kasey E. Moritz and Kimberly R. Byrnes

    Journal of Neuroinflammation 2017 14:161

    Published on: 18 August 2017

  4. Research

    Candidate inflammatory biomarkers display unique relationships with alpha-synuclein and correlate with measures of disease severity in subjects with Parkinson’s disease

    Efforts to identify fluid biomarkers of Parkinson’s disease (PD) have intensified in the last decade. As the role of inflammation in PD pathophysiology becomes increasingly recognized, investigators aim to def...

    Lori N. Eidson, George T. Kannarkat, Christopher J. Barnum, Jianjun Chang, Jaegwon Chung, Chelsea Caspell-Garcia, Peggy Taylor, Brit Mollenhauer, Michael G. Schlossmacher, Larry Ereshefsky, Mark Yen, Catherine Kopil, Mark Frasier, Kenneth Marek, Vicki S. Hertzberg and Malú G. Tansey

    Journal of Neuroinflammation 2017 14:164

    Published on: 18 August 2017

  5. Review

    Regulation of inflammation in Japanese encephalitis

    Uncontrolled inflammatory response of the central nervous system is a hallmark of severe Japanese encephalitis (JE). Although inflammation is necessary to mount an efficient immune response against virus infec...

    Nils Lannes, Artur Summerfield and Luis Filgueira

    Journal of Neuroinflammation 2017 14:158

    Published on: 14 August 2017

  6. Research

    microRNA dysregulation in polyglutamine toxicity of TATA-box binding protein is mediated through STAT1 in mouse neuronal cells

    Polyglutamine diseases constitute a class of neurodegenerative disorders associated with expansion of the cytosine-adenine-guanine (CAG) triplet, in protein coding genes. Expansion of a polyglutamine tract in ...

    Reema Roshan, Ashwani Choudhary, Aksheev Bhambri, Bhawani Bakshi, Tanay Ghosh and Beena Pillai

    Journal of Neuroinflammation 2017 14:155

    Published on: 3 August 2017

  7. Research

    Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation

    PINK1 deficiency causes the autosomal recessive PARK6 variant of Parkinson’s disease. PINK1 activates ubiquitin by phosphorylation and cooperates with the downstream ubiquitin ligase PARKIN, to exert quality c...

    Sylvia Torres-Odio, Jana Key, Hans-Hermann Hoepken, Júlia Canet-Pons, Lucie Valek, Bastian Roller, Michael Walter, Blas Morales-Gordo, David Meierhofer, Patrick N. Harter, Michel Mittelbronn, Irmgard Tegeder, Suzana Gispert and Georg Auburger

    Journal of Neuroinflammation 2017 14:154

    Published on: 2 August 2017

  8. Research

    Sensitization of ASIC3 by proteinase-activated receptor 2 signaling contributes to acidosis-induced nociception

    Tissue acidosis and inflammatory mediators play critical roles in pain. Pro-inflammatory agents trypsin and tryptase cleave and activate proteinase-activated receptor 2 (PAR2) expressed on sensory nerves, which i...

    Jing Wu, Ting-Ting Liu, Yi-Mei Zhou, Chun-Yu Qiu, Ping Ren, Ming Jiao and Wang-Ping Hu

    Journal of Neuroinflammation 2017 14:150

    Published on: 28 July 2017

  9. Research

    Choroid plexus-cerebrospinal fluid route for monocyte-derived macrophages after stroke

    Choroid plexus (CP) supports the entry of monocyte-derived macrophages (MDMs) to the central nervous system in animal models of traumatic brain injury, spinal cord injury, and Alzheimer’s disease. Whether the ...

    Ruimin Ge, Daniel Tornero, Masao Hirota, Emanuela Monni, Cecilia Laterza, Olle Lindvall and Zaal Kokaia

    Journal of Neuroinflammation 2017 14:153

    Published on: 28 July 2017

  10. Research

    Adaptive lymphocyte profiles correlate to brain Aβ burden in patients with mild cognitive impairment

    We previously found that subjects with amnestic mild cognitive impairment exhibit a pro-inflammatory immune profile in the cerebrospinal fluid similar to multiple sclerosis, a central nervous system autoimmune...

    Ann M. Stowe, Sara J. Ireland, Sterling B. Ortega, Ding Chen, Ryan M. Huebinger, Takashi Tarumi, Thomas S. Harris, C. Munro Cullum, Roger Rosenberg, Nancy L. Monson and Rong Zhang

    Journal of Neuroinflammation 2017 14:149

    Published on: 27 July 2017

  11. Research

    Differential effects of FTY720 on the B cell compartment in a mouse model of multiple sclerosis

    MP4-induced experimental autoimmune encephalomyelitis (EAE) is a mouse model of multiple sclerosis (MS), which enables targeted research on B cells, currently much discussed protagonists in MS pathogenesis. He...

    Kathrin Bail, Quirin Notz, Damiano M. Rovituso, Andrea Schampel, Marie Wunsch, Tobias Koeniger, Verena Schropp, Richa Bharti, Claus-Juergen Scholz, Konrad U. Foerstner, Christoph Kleinschnitz and Stefanie Kuerten

    Journal of Neuroinflammation 2017 14:148

    Published on: 24 July 2017

  12. Research

    Omega-3 polyunsaturated fatty acid supplementation attenuates microglial-induced inflammation by inhibiting the HMGB1/TLR4/NF-κB pathway following experimental traumatic brain injury

    Microglial activation and the subsequent inflammatory response in the central nervous system play important roles in secondary damage after traumatic brain injury (TBI). High-mobility group box 1 (HMGB1) prote...

    Xiangrong Chen, Shukai Wu, Chunnuan Chen, Baoyuan Xie, Zhongning Fang, Weipeng Hu, Junyan Chen, Huangde Fu and Hefan He

    Journal of Neuroinflammation 2017 14:143

    Published on: 24 July 2017

  13. Research

    TLR4 response mediates ethanol-induced neurodevelopment alterations in a model of fetal alcohol spectrum disorders

    Inflammation during brain development participates in the pathogenesis of early brain injury and cognitive dysfunctions. Prenatal ethanol exposure affects the developing brain and causes neural impairment, cog...

    María Pascual, Jorge Montesinos, Sandra Montagud-Romero, Jerónimo Forteza, Marta Rodríguez-Arias, José Miñarro and Consuelo Guerri

    Journal of Neuroinflammation 2017 14:145

    Published on: 24 July 2017

  14. Research

    Increased interleukin-27 cytokine expression in the central nervous system of multiple sclerosis patients

    Multiple sclerosis (MS) is an autoimmune disorder characterized by chronic inflammation, demyelination, and neuronal damage. During autoimmunity, cytokines are important mediators of the inflammation. In this ...

    Patrice H. Lalive, Mario Kreutzfeldt, Odile Devergne, Imke Metz, Wolfgang Bruck, Doron Merkler and Caroline Pot

    Journal of Neuroinflammation 2017 14:144

    Published on: 24 July 2017

  15. Research

    Chronic glucocorticoid exposure activates BK-NLRP1 signal involving in hippocampal neuron damage

    Neuroinflammation mediated by NLRP1 (nucleotide-binding oligomerization domain (NOD)-like receptor protein 1) inflammasome plays an important role in many neurological diseases such as Parkinson’s disease (PD)...

    Biqiong Zhang, Yaodong Zhang, Wenning Wu, Tanzhen Xu, Yanyan Yin, Junyan Zhang, Dake Huang and Weizu Li

    Journal of Neuroinflammation 2017 14:139

    Published on: 21 July 2017

  16. Research

    Protective and therapeutic role of 2-carba-cyclic phosphatidic acid in demyelinating disease

    Multiple sclerosis is a neuroinflammatory demyelinating and neurodegenerative disease of the central nervous system characterized by recurrent and progressive demyelination/remyelination cycles, neuroinflammat...

    Shinji Yamamoto, Kota Yamashina, Masaki Ishikawa, Mari Gotoh, Sosuke Yagishita, Kensuke Iwasa, Kei Maruyama, Kimiko Murakami-Murofushi and Keisuke Yoshikawa

    Journal of Neuroinflammation 2017 14:142

    Published on: 21 July 2017

  17. Research

    Sexually divergent induction of microglial-associated neuroinflammation with hippocampal aging

    The necessity of including both males and females in molecular neuroscience research is now well understood. However, there is relatively limited basic biological data on brain sex differences across the lifes...

    Colleen A. Mangold, Benjamin Wronowski, Mei Du, Dustin R. Masser, Niran Hadad, Georgina V. Bixler, Robert M. Brucklacher, Matthew M. Ford, William E. Sonntag and Willard M. Freeman

    Journal of Neuroinflammation 2017 14:141

    Published on: 21 July 2017

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