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  1. Content type: Research

    Understanding the interdependencies among inflammatory mediators of tissue damage following traumatic brain injury (TBI) is essential in providing effective, patient-specific care. Activated microglia and elev...

    Authors: Leah E. Vaughan, Prerna R. Ranganathan, Raj G. Kumar, Amy K. Wagner and Jonathan E. Rubin

    Citation: Journal of Neuroinflammation 2018 15:345

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  2. Content type: Research

    Activation of resident microglia accompanies every known form of neurodegeneration, but the involvement of peripheral monocytes that extravasate and rapidly transform into microglia-like macrophages within the...

    Authors: Sarah J. Karlen, Eric B. Miller, Xinlei Wang, Emily S. Levine, Robert J. Zawadzki and Marie E. Burns

    Citation: Journal of Neuroinflammation 2018 15:344

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  3. Content type: Research

    Over-activated microglia play a central role during neuroinflammation, leading to neuronal cell death and neurodegeneration. Reversion of over-activated to neuroprotective microglia phenotype could regenerate ...

    Authors: Veronika E. Neubrand, Irene Forte-Lago, Marta Caro and Mario Delgado

    Citation: Journal of Neuroinflammation 2018 15:343

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  4. Content type: Research

    Although the mechanisms underlying AD neurodegeneration are not fully understood, it is now recognised that inflammation could play a crucial role in the initiation and progression of AD neurodegeneration. A n...

    Authors: Paola Italiani, Ilaria Puxeddu, Sabrina Napoletano, Emanuele Scala, Daniela Melillo, Simone Manocchio, Antonella Angiolillo, Paola Migliorini, Diana Boraschi, Emilia Vitale and Alfonso Di Costanzo

    Citation: Journal of Neuroinflammation 2018 15:342

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  5. Content type: Research

    Microglia-associated inflammation is closely related to the pathogenesis of various retinal diseases such as uveitis and diabetic retinopathy, which are associated with increased vascular permeability. In this...

    Authors: Despina Kokona, Andreas Ebneter, Pascal Escher and Martin S. Zinkernagel

    Citation: Journal of Neuroinflammation 2018 15:340

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  6. Content type: Review

    Methamphetamine (METH) is an illicit psychostimulant that is subject to abuse worldwide. While the modulatory effects of METH on dopamine neurotransmission and its neurotoxicity in the central nervous system a...

    Authors: Fatemeh Shaerzadeh, Wolfgang J. Streit, Soomaayeh Heysieattalab and Habibeh Khoshbouei

    Citation: Journal of Neuroinflammation 2018 15:341

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  7. Content type: Review

    Emerging evidence suggests that gut-brain-microbiota axis (GBMAx) may play a pivotal role linking gastrointestinal and neuronal disease. In this review, we summarize the latest advances in studies of GBMAx in ...

    Authors: Liang Zhao, Qiutang Xiong, Creed M. Stary, Omer Kamal Mahgoub, Yingze Ye, Lijuan Gu, Xiaoxing Xiong and Shengmei Zhu

    Citation: Journal of Neuroinflammation 2018 15:339

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  8. Content type: Research

    Neuroinflammation has recently emerged as a critical risk factor in the pathophysiology of depression. However, the underlying molecular mechanisms and the development of novel therapeutic strategies as means ...

    Authors: Qiqi Song, Cuiqin Fan, Peng Wang, Ye Li, Mu Yang and Shu Yan Yu

    Citation: Journal of Neuroinflammation 2018 15:338

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  9. Content type: Research

    Perinatal maternal malnutrition is related to altered growth of tissues and organs. The nervous system development is very sensitive to environmental insults, being the hippocampus a vulnerable structure, in w...

    Authors: Y. Diz-Chaves, L. Toba, J. Fandiño, L. C. González-Matías, L. M. Garcia-Segura and F. Mallo

    Citation: Journal of Neuroinflammation 2018 15:337

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  10. Content type: Research

    The extension of sepsis encompassing the preterm newborn’s brain is often overlooked due to technical challenges in this highly vulnerable population, yet it leads to substantial long-term neurodevelopmental d...

    Authors: Ekaterina P. Demina, Wyston C. Pierre, Annie L. A. Nguyen, Irene Londono, Bela Reiz, Chunxia Zou, Radhika Chakraberty, Christopher W. Cairo, Alexey V. Pshezhetsky and Gregory A. Lodygensky

    Citation: Journal of Neuroinflammation 2018 15:336

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  11. Content type: Research

    The regulatory role of capsaicin-sensitive peptidergic sensory nerves has been shown in acute inflammation, but little is known about their involvement in T/B-cell driven autoimmune arthritis. This study integ...

    Authors: Ádám Horváth, Éva Borbély, Kata Bölcskei, Nikolett Szentes, Tamás Kiss, Mátyás Belák, Tibor Rauch, Tibor Glant, Róza Zákány, Tamás Juhász, Edina Karanyicz, Ferenc Boldizsár, Zsuzsanna Helyes and Bálint Botz

    Citation: Journal of Neuroinflammation 2018 15:335

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  12. Content type: Research

    Parkinson’s disease (PD) is the second most common neurodegenerative disease, presenting with midbrain dopaminergic neurons degeneration. A number of studies suggest that microglial activation may have a role ...

    Authors: Stephana Carelli, Toniella Giallongo, Zuzana Gombalova, Federica Rey, Maria Carlotta F. Gorio, Massimiliano Mazza and Anna Maria Di Giulio

    Citation: Journal of Neuroinflammation 2018 15:333

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  13. Content type: Research

    Inflammatory reaction plays a crucial role in cerebral ischemia reperfusion (IR) injury. It has been shown that activated microglia long-term existed in cerebral ischemia and induced second injury. Therefore, ...

    Authors: Ranran Zhao, Jie Jiang, Huiwen Li, Min Chen, Renfa Liu, Sujuan Sun, De Ma, Xiaolong Liang and Shumin Wang

    Citation: Journal of Neuroinflammation 2018 15:334

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  14. Content type: Research

    Lipocalin 2 (Lcn2) is an acute-phase protein implicated in multiple neurodegenerative conditions. Interestingly, both neuroprotective and neurodegenerative effects have been described for Lcn2. Increased Lcn2 ...

    Authors: Doortje W. Dekens, Petrus J. W. Naudé, Jan N. Keijser, Ate S. Boerema, Peter P. De Deyn and Ulrich L. M. Eisel

    Citation: Journal of Neuroinflammation 2018 15:330

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  15. Content type: Research

    Perioperative neurocognitive disorders (PND) occur frequently after surgery, especially in aged patients. Surgery-induced neuroinflammation and blood-brain barrier (BBB) dysfunction play a crucial role in the ...

    Authors: Pengfei Ni, Hongquan Dong, Yiwei Wang, Qin Zhou, Mengmeng Xu, Yanning Qian and Jie Sun

    Citation: Journal of Neuroinflammation 2018 15:332

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  16. Content type: Research

    Neuroprotective strategies are becoming relevant to slow down dopaminergic cell death and inflammatory processes related to the progressive neurodegeneration in Parkinson’s disease (PD). Interestingly, among o...

    Authors: Ana-Luisa Gil-Martínez, Lorena Cuenca, Consuelo Sánchez, Cristina Estrada, Emiliano Fernández-Villalba and María Trinidad Herrero

    Citation: Journal of Neuroinflammation 2018 15:328

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  17. Content type: Research

    Few studies have suggested a relationship between inflammation and cerebral venous thrombosis (CVT). This retrospective study aimed to explore the changes in inflammation in different CVT stages and the correl...

    Authors: Liyan Wang, Jiangang Duan, Tingting Bian, Ran Meng, Longfei Wu, Zhen Zhang, Xuxiang Zhang, Chunxiu Wang and Xunming Ji

    Citation: Journal of Neuroinflammation 2018 15:329

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  18. Content type: Research

    The host response to intruders in the central nervous system (CNS) may be beneficial but could also be harmful and responsible for neurologic symptoms and sequelae in CNS infections. This immune response induc...

    Authors: Else Quist-Paulsen, Pål Aukrust, Anne-Marte Bakken Kran, Oona Dunlop, Vidar Ormaasen, Birgitte Stiksrud, Øivind Midttun, Thor Ueland, Per Magne Ueland, Tom Eirik Mollnes and Anne Ma Dyrhol-Riise

    Citation: Journal of Neuroinflammation 2018 15:327

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  19. Content type: Research

    Recent evidence suggests that reactive astrocytes play an important role in neuroinflammation and neurodegenerative diseases. Thus, controlling astrocyte reactivity has been suggested as a promising strategy f...

    Authors: Eun-Jung Lee, Jin-Sun Park, Yu-Young Lee, Do-Yeon Kim, Jihee Lee Kang and Hee-Sun Kim

    Citation: Journal of Neuroinflammation 2018 15:326

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  20. Content type: Research

    Exposure to increased manganese (Mn) causes inflammation and neuronal injury in the cortex and basal ganglia, resulting in neurological symptoms resembling Parkinson’s disease. The mechanisms underlying neuron...

    Authors: Katriana A. Popichak, Maryam F. Afzali, Kelly S. Kirkley and Ronald B. Tjalkens

    Citation: Journal of Neuroinflammation 2018 15:324

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  21. Content type: Research

    The ATP-gated ionotropic P2X7 receptor (P2X7R) has the unusual ability to function as a small cation channel and a trigger for permeabilization of plasmalemmal membranes. In murine microglia, P2X7R-mediated pe...

    Authors: Laura Janks, Cristian V. R. Sharma and Terrance M. Egan

    Citation: Journal of Neuroinflammation 2018 15:325

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  22. Content type: Research

    Traumatic brain injury (TBI) represents a major cause of disability and death worldwide with sustained neuroinflammation and autophagy dysfunction contributing to the cellular damage. Stimulator of interferon ...

    Authors: Amar Abdullah, Moses Zhang, Tony Frugier, Sammy Bedoui, Juliet M. Taylor and Peter J. Crack

    Citation: Journal of Neuroinflammation 2018 15:323

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  23. Content type: Research

    Neuroinflammation plays a vital role in Alzheimer’s disease and other neurodegenerative conditions. Microglia are the resident mononuclear immune cells of the central nervous system, and they play essential ro...

    Authors: Soraya Wilke Saliba, Hannah Jauch, Brahim Gargouri, Albrecht Keil, Thomas Hurrle, Nicole Volz, Florian Mohr, Mario van der Stelt, Stefan Bräse and Bernd L. Fiebich

    Citation: Journal of Neuroinflammation 2018 15:322

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  24. Content type: Research

    Pharmaceutical treatment with probable anti-inflammatory substances that attack cells in various ways including receptors, ion channels, or transporter systems may slow down the progression of inflammatory con...

    Authors: Elisabeth Hansson, Ulrika Björklund, Eva Skiöldebrand and Lars Rönnbäck

    Citation: Journal of Neuroinflammation 2018 15:321

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  25. Content type: Research

    La Crosse virus (LACV) causes pediatric encephalitis in the USA. LACV induces severe inflammation in the central nervous system, but the recruitment of inflammatory cells is poorly understood. A deeper underst...

    Authors: Brian E. Dawes, Junling Gao, Colm Atkins, Jacob T. Nelson, Kendra Johnson, Ping Wu and Alexander N. Freiberg

    Citation: Journal of Neuroinflammation 2018 15:315

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  26. Content type: Research

    Varicella zoster virus (VZV) is a ubiquitous alphaherpesvirus that produces varicella and zoster. VZV can infect multiple cell types in the spinal cord and brain, including astrocytes, producing myelopathy and...

    Authors: Andrew N. Bubak, Christina N. Como, Anna M. Blackmon, Dallas Jones and Maria A. Nagel

    Citation: Journal of Neuroinflammation 2018 15:318

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  27. Content type: Research

    Preemptive administration of analgesic drugs reduces perceived pain and prolongs duration of antinociceptive action. Whereas several lines of evidence suggest that endomorphins, the endogenous mu-opioid agonis...

    Authors: Ting Zhang, Nan Zhang, Run Zhang, Weidong Zhao, Yong Chen, Zilong Wang, Biao Xu, Mengna Zhang, Xuerui Shi, Qinqin Zhang, Yuanyuan Guo, Jian Xiao, Dan Chen and Quan Fang

    Citation: Journal of Neuroinflammation 2018 15:320

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  28. Content type: Research

    The intermediate-conductance Ca2+-activated K+ channel KCa3.1 was recently shown to control the phenotype switch of reactive astrogliosis (RA) in Alzheimer’s disease (AD).

    Authors: Zhihua Yu, Fangfang Dou, Yanxia Wang, Lina Hou and Hongzhuan Chen

    Citation: Journal of Neuroinflammation 2018 15:316

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  29. Content type: Research

    The development of intracranial hemorrhage (ICH) in acute ischemic stroke is associated with a higher neutrophil to lymphocyte ratio (NLR) in peripheral blood. Here, we studied whether the predictive value of ...

    Authors: Slaven Pikija, Laszlo K. Sztriha, Monika Killer-Oberpfalzer, Friedrich Weymayr, Constantin Hecker, Christian Ramesmayer, Larissa Hauer and Johann Sellner

    Citation: Journal of Neuroinflammation 2018 15:319

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  30. Content type: Correction

    Upon publication of the original article [1], it was noticed that there is an error in Fig. 10, the dialog box in panel (b) was missing. The correct Fig. 10 is shown below.

    Authors: Shalini Swaroop, Anita Mahadevan, Susarla Krishna Shankar, Yogita K. Adlakha and Anirban Basu

    Citation: Journal of Neuroinflammation 2018 15:317

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    The original article was published in Journal of Neuroinflammation 2018 15:177

  31. Content type: Research

    Glaucoma is a chronic degenerative disease for which inflammation is considered to play a pivotal role in the pathogenesis and progression. In this study, we examined the impact of a ketogenic diet on the infl...

    Authors: Mohammad Harun-Or-Rashid and Denise M. Inman

    Citation: Journal of Neuroinflammation 2018 15:313

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  32. Content type: Research

    Over the past decades, positron emission tomography (PET) imaging has become an increasingly useful research modality in the field of multiple sclerosis (MS) research, as PET can visualise molecular processes,...

    Authors: Marloes H. J. Hagens, Sandeep V. Golla, Martijn T. Wijburg, Maqsood Yaqub, Dennis Heijtel, Martijn D. Steenwijk, Patrick Schober, John J. P. Brevé, Robert C. Schuit, Tristan A. Reekie, Michael Kassiou, Anne-Marie van Dam, Albert D. Windhorst, Joep Killestein, Frederik Barkhof, Bart N. M. van Berckel…

    Citation: Journal of Neuroinflammation 2018 15:314

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  33. Content type: Research

    TDP-43 has been identified as a disease-associated protein in several chronic neurodegenerative disorders and increasing evidence suggests its potentially pathogenic role following brain injuries. Normally exp...

    Authors: Sai Sampath Thammisetty, Jordi Pedragosa, Yuan Cheng Weng, Frédéric Calon, Anna Planas and Jasna Kriz

    Citation: Journal of Neuroinflammation 2018 15:312

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  34. Content type: Research

    Activation of inflammation pathways in the brain occurs in Alzheimer’s disease and may contribute to the accumulation and spread of pathological proteins including tau. The goal of this study was to identify h...

    Authors: Rachel E. Bennett, Annie Bryant, Miwei Hu, Ashley B. Robbins, Sarah C. Hopp and Bradley T. Hyman

    Citation: Journal of Neuroinflammation 2018 15:311

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  35. Content type: Research

    Enhancing autophagy after traumatic brain injury (TBI) may decrease the expression of neuronal apoptosis-related molecules. Autophagy-mediated neuronal survival is regulated by the sirtuin family of proteins (...

    Authors: Xiangrong Chen, Zhigang Pan, Zhongning Fang, Weibin Lin, Shukai Wu, Fuxing Yang, Yasong Li, Huangde Fu, Hongzhi Gao and Shun Li

    Citation: Journal of Neuroinflammation 2018 15:310

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  36. Content type: Research

    Causal associations between microglia activation and β-amyloid (Aβ) accumulation during the progression of Alzheimer’s disease (AD) remain a matter of controversy. Therefore, we used longitudinal dual tracer i...

    Authors: Tanja Blume, Carola Focke, Finn Peters, Maximilian Deussing, Nathalie L. Albert, Simon Lindner, Franz-Josef Gildehaus, Barbara von Ungern-Sternberg, Laurence Ozmen, Karlheinz Baumann, Peter Bartenstein, Axel Rominger, Jochen Herms and Matthias Brendel

    Citation: Journal of Neuroinflammation 2018 15:307

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  37. Content type: Research

    Neuroinflammation often develops in sepsis leading to activation of cerebral endothelium, increased permeability of the blood-brain barrier (BBB), and neutrophil infiltration. We have identified protein kinase...

    Authors: Yuan Tang, Fariborz Soroush, Shuang Sun, Elisabetta Liverani, Jordan C. Langston, Qingliang Yang, Laurie E. Kilpatrick and Mohammad F. Kiani

    Citation: Journal of Neuroinflammation 2018 15:309

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  38. Content type: Research

    Inflammation plays a critical role in accelerating the progression of neurodegenerative diseases, such as Alzheimer’s disease (AD) and ataxia telangiectasia (A-T). In A-T mouse models, LPS-induced neuroinflamm...

    Authors: Chin Wai Hui, Xuan Song, Fulin Ma, Xuting Shen and Karl Herrup

    Citation: Journal of Neuroinflammation 2018 15:308

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  39. Content type: Research

    Delirium and dementia share symptoms of cognitive dysfunctions, and mechanisms of neuroinflammation appear involved in both conditions. Triggering receptor expressed on myeloid cells 2 (TREM2) is linked to dement...

    Authors: Kristi Henjum, Else Quist-Paulsen, Henrik Zetterberg, Kaj Blennow, Lars N. G. Nilsson and Leiv Otto Watne

    Citation: Journal of Neuroinflammation 2018 15:304

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  40. Content type: Research

    Neuroinflammation has been established to be part of the neuropathological changes in Parkinson’s disease (PD) and atypical parkinsonism (APD). Activated microglia play a key role in neuroinflammation by relea...

    Authors: C. Starhof, K. Winge, N. H. H. Heegaard, K. Skogstrand, S. Friis and A. Hejl

    Citation: Journal of Neuroinflammation 2018 15:305

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  41. Content type: Research

    HIV-associated neurocognitive disorder (HAND) is a neurodegenerative disease associated with persistent neuroinflammation and subsequent neuron damage. Pro-inflammatory factors and neurotoxins from activated a...

    Authors: Feng Zhou, Xiaomei Liu, Dongjiao Zuo, Min Xue, Lin Gao, Ying Yang, Jing Wang, Liping Niu, Qianwen Cao, Xiangyang Li, Hui Hua, Bo Zhang, Minmin Hu, Dianshuai Gao, Kuiyang Zheng, Yoshihiro Izumiya…

    Citation: Journal of Neuroinflammation 2018 15:303

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  42. Content type: Research

    Key clinical features of chronic relapsing inflammatory optic neuropathy (CRION) include relapsing inflammatory optic neuritis (ON) and steroid dependency, both of which have been reported among patients with ...

    Authors: Haeng-Jin Lee, Boram Kim, Patrick Waters, Mark Woodhall, Sarosh Irani, Sohyun Ahn, Seong-Joon Kim and Sung-Min Kim

    Citation: Journal of Neuroinflammation 2018 15:302

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  43. Content type: Research

    Neonatal brain injury is increasingly understood to be linked to inflammatory processes that involve specialised CNS and peripheral immune interactions. However, the role of peripheral myeloid cells in neonata...

    Authors: Peter L. P. Smith, Amin Mottahedin, Pernilla Svedin, Carl-Johan Mohn, Henrik Hagberg, Joakim Ek and Carina Mallard

    Citation: Journal of Neuroinflammation 2018 15:301

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  44. Content type: Research

    Regulatory B cells (Bregs), which protect from autoimmunity, are deficient in multiple sclerosis (MS). Novel regulatory B cell subsets CD19+CD24hiCD38hi cells and CD19+PD-L1hi cells, with disparate regulatory mec...

    Authors: Yeseul Kim, Gayoung Kim, Hyun-June Shin, Jae-Won Hyun, Su-Hyun Kim, Eunjig Lee and Ho Jin Kim

    Citation: Journal of Neuroinflammation 2018 15:300

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  45. Content type: Research

    Although studies have reported an increased risk for mood disorders in Hashimoto’s thyroiditis (HT) patients even in the euthyroid state, the mechanisms involved remain unclear. Neuroinflammation may play a ke...

    Authors: Yao-Jun Cai, Fen Wang, Zhang-Xiang Chen, Li Li, Hua Fan, Zhang-Bi Wu, Jin-Fang Ge, Wen Hu, Qu-Nan Wang and De-Fa Zhu

    Citation: Journal of Neuroinflammation 2018 15:299

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  46. Content type: Research

    The end-organ effects of alcohol span throughout the entire body, from the gastrointestinal tract to the central nervous system (CNS). In the intestine, alcohol use changes the microbiome composition and incre...

    Authors: Patrick P. Lowe, Benedek Gyongyosi, Abhishek Satishchandran, Arvin Iracheta-Vellve, Yeonhee Cho, Aditya Ambade and Gyongyi Szabo

    Citation: Journal of Neuroinflammation 2018 15:298

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  47. Content type: Research

    Evidence indicates a cross-regulation between two kinases, leucine-rich repeat kinase 2 (LRRK2) and protein kinase A (PKA). In neurons, LRRK2 negatively regulates PKA activity in spiny projecting neurons durin...

    Authors: Isabella Russo, Giulietta Di Benedetto, Alice Kaganovich, Jinhui Ding, Daniela Mercatelli, Michele Morari, Mark R. Cookson, Luigi Bubacco and Elisa Greggio

    Citation: Journal of Neuroinflammation 2018 15:297

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  48. Content type: Research

    Recent studies in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis (MS), suggest an involvement of the histone methyltransferase enhancer of zeste 2 polycomb repressive complex ...

    Authors: Sunny Malhotra, Luisa M. Villar, Carme Costa, Luciana Midaglia, Marta Cubedo, Silvia Medina, Nicolás Fissolo, Jordi Río, Joaquín Castilló, José C. Álvarez-Cermeño, Alex Sánchez, Xavier Montalban and Manuel Comabella

    Citation: Journal of Neuroinflammation 2018 15:296

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