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Journal of Neuroinflammation


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  1. Content type: Research

    Gulf War illness (GWI) is an archetypal, medically unexplained, chronic condition characterised by persistent sickness behaviour and neuroimmune and neuroinflammatory components. An estimated 25–32% of the ove...

    Authors: David G. Ashbrook, Benjamin Hing, Lindsay T. Michalovicz, Kimberly A. Kelly, Julie V. Miller, Wilfred C. de Vega, Diane B. Miller, Gordon Broderick, James P. O’Callaghan and Patrick O. McGowan

    Citation: Journal of Neuroinflammation 2018 15:86

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  2. Content type: Research

    The retinal pigment epithelium (RPE) is a monolayer of pigmented cells with important barrier and immuno-suppressive functions in the eye. We have previously shown that acute stimulation of RPE cells by tumor ...

    Authors: Sara Touhami, Fanny Beguier, Sébastien Augustin, Hugo Charles-Messance, Lucile Vignaud, Emeline F. Nandrot, Sacha Reichman, Valérie Forster, Thibaud Mathis, José-Alain Sahel, Bahram Bodaghi, Xavier Guillonneau and Florian Sennlaub

    Citation: Journal of Neuroinflammation 2018 15:85

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  3. Content type: Research

    Traumatic brain injury (TBI) is a major cause of death and disability. TBI results in a prolonged secondary central neuro-inflammatory response. Previously, we have demonstrated that multiple doses (2 and 24 h...

    Authors: Supinder S. Bedi, Benjamin M. Aertker, George P. Liao, Henry W. Caplan, Deepa Bhattarai, Fanni Mandy, Franciska Mandy, Luis G. Fernandez, Pamela Zelnick, Matthew B. Mitchell, Walter Schiffer, Margaret Johnson, Emma Denson, Karthik Prabhakara, Hasen Xue, Philippa Smith…

    Citation: Journal of Neuroinflammation 2018 15:84

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  4. Content type: Research

    Ischemic stroke-induced neuroinflammation is mainly mediated by microglial cells. The nuclear factor kappa B (NF-κB) pathway is the key transcriptional pathway that initiates inflammatory responses following c...

    Authors: Hongbei Xu, Wenyi Qin, Xiao Hu, Song Mu, Jun Zhu, Wenhao Lu and Yong Luo

    Citation: Journal of Neuroinflammation 2018 15:83

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  5. Content type: Research

    Hyperglycemia is common in extremely low gestational age newborns (ELGAN) and is associated with increased mortality and morbidity, including abnormal neurodevelopment. Hippocampus-mediated cognitive deficits ...

    Authors: Katherine M. Satrom, Kathleen Ennis, Brian M. Sweis, Tatyana M. Matveeva, Jun Chen, Leif Hanson, Akhil Maheshwari and Raghavendra Rao

    Citation: Journal of Neuroinflammation 2018 15:82

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  6. Content type: Research

    Flaviviruses are a group of diverse and emerging arboviruses and an immense global health problem. A number of flaviviruses are neurotropic, causing severe encephalitis and even death. Type I interferons (IFNs...

    Authors: Richard Lindqvist, Chaitanya Kurhade, Jonathan D. Gilthorpe and Anna K. Överby

    Citation: Journal of Neuroinflammation 2018 15:80

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  7. Content type: Short report

    Antigen-specific and MHCII-restricted CD4+ αβ T cells have been shown or suggested to play an important role in the transition from acute to chronic mechanical allodynia after peripheral nerve injuries. Howeve...

    Authors: Bin Du, You-Quan Ding, Xia Xiao, Hong-Yi Ren, Bing-Yin Su and Jian-Guo Qi

    Citation: Journal of Neuroinflammation 2018 15:81

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  8. Content type: Research

    Acute ischemic stroke (AIS) is the most common type of cerebrovascular disease and is a leading cause of disability and death worldwide. Recently, a study suggested that transformation of microglia from the pr...

    Authors: Mei Jiang, Xinghui Liu, Denghai Zhang, Ying Wang, Xiaoxia Hu, Fengxia Xu, Mingming Jin, Fanfan Cao and Limin Xu

    Citation: Journal of Neuroinflammation 2018 15:78

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  9. Content type: Research

    Extracellular vesicles (EVs) are important in the intercellular communication of the central nervous system, and their release is increased during neuroinflammation. Our previous data demonstrated an increased...

    Authors: Beiqing Wu, Jianhui Liu, Runze Zhao, Yuju Li, Justin Peer, Alexander L. Braun, Lixia Zhao, Yi Wang, Zenghan Tong, Yunlong Huang and Jialin C. Zheng

    Citation: Journal of Neuroinflammation 2018 15:79

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  10. Content type: Research

    Multiple sclerosis (MS) is a neuroinflammatory autoimmune disease of the central nervous system (CNS) which in most cases initially presents with episodes of transient functional deficits (relapsing-remitting ...

    Authors: Peter Göttle, Anastasia Manousi, David Kremer, Laura Reiche, Hans-Peter Hartung and Patrick Küry

    Citation: Journal of Neuroinflammation 2018 15:76

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  11. Content type: Research

    The therapeutic efficacy of adipose-derived stem cells (ASCs) has been investigated for numerous clinical indications, including autoimmune and neurodegenerative diseases. Less is known using the crude adipose...

    Authors: Annie C. Bowles, Rachel M. Wise, Brittany Y. Gerstein, Robert C. Thomas, Roberto Ogelman, Regan C. Manayan and Bruce A. Bunnell

    Citation: Journal of Neuroinflammation 2018 15:77

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  12. Content type: Research

    Mer tyrosine kinase (MerTK) activity necessary for amyloid-stimulated phagocytosis strongly implicates that MerTK dysregulation might contribute to chronic inflammation implicated in Alzheimer’s disease (AD) p...

    Authors: Kyoung A. Jhang, Jin-Sun Park, Hee-Sun Kim and Young Hae Chong

    Citation: Journal of Neuroinflammation 2018 15:75

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  13. Content type: Research

    Oxysterols are cholesterol derivatives that have been suggested to play a role in inflammatory diseases such as obesity, atherosclerosis, or neuroinflammatory diseases. However, the effect of neuroinflammation...

    Authors: Valentin Mutemberezi, Baptiste Buisseret, Julien Masquelier, Owein Guillemot-Legris, Mireille Alhouayek and Giulio G. Muccioli

    Citation: Journal of Neuroinflammation 2018 15:74

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  14. Content type: Research

    Neuroinflammation is one of the hallmarks of neurodegenerative diseases, such as Parkinson’s disease (PD). Activation of glial cells, including microglia and astrocytes, is a characteristic of the inflammatory...

    Authors: Matthew L. Neal, Alexa M. Boyle, Kevin M. Budge, Fayez F. Safadi and Jason R. Richardson

    Citation: Journal of Neuroinflammation 2018 15:73

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  15. Content type: Research

    In multiple sclerosis (MS), neurodegeneration is the main reason for chronic disability. Alpha-lipoic acid (LA) is a naturally occurring antioxidant which has recently been demonstrated to reduce the rate of b...

    Authors: Michael Dietrich, Niklas Helling, Alexander Hilla, Annemarie Heskamp, Andrea Issberner, Thomas Hildebrandt, Zippora Kohne, Patrick Küry, Carsten Berndt, Orhan Aktas, Dietmar Fischer, Hans-Peter Hartung and Philipp Albrecht

    Citation: Journal of Neuroinflammation 2018 15:71

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  16. Content type: Research

    Multiple sclerosis (MS) is characterized by increased activation of peripheral blood mononuclear cells (PBMCs), linked to perturbations in the phosphorylation of signaling proteins.

    Authors: Ester Canto, Noriko Isobe, Alessandro Didonna, Stephen L. Hauser and Jorge R. Oksenberg

    Citation: Journal of Neuroinflammation 2018 15:72

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  17. Content type: Research

    Heme oxygenase-1 (HO-1) is a critical cytoprotective enzyme that limits oxidative stress, inflammation, and cellular injury within the central nervous system (CNS) and other tissues. We previously demonstrated...

    Authors: Alexander J. Gill, Rolando Garza, Surendra S. Ambegaokar, Benjamin B. Gelman and Dennis L. Kolson

    Citation: Journal of Neuroinflammation 2018 15:70

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  18. Content type: Research

    Cerebral microhemorrhages (CMH) are commonly found in the aging brain. CMH are also the neuropathological substrate of cerebral microbleeds (CMB), demonstrated on brain MRI. Recent studies demonstrate the impo...

    Authors: Rachita K. Sumbria, Mher Mahoney Grigoryan, Vitaly Vasilevko, Annlia Paganini-Hill, Kelley Kilday, Ronald Kim, David H. Cribbs and Mark J. Fisher

    Citation: Journal of Neuroinflammation 2018 15:69

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  19. Content type: Research

    Peripheral neuropathy is currently the most common neurological complication in HIV-infected individuals, occurring in 35–50% of patients undergoing combination anti-retroviral therapy. Data have shown that di...

    Authors: Priyanka Chauhan, Wen S. Sheng, Shuxian Hu, Sujata Prasad and James R. Lokensgard

    Citation: Journal of Neuroinflammation 2018 15:66

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  20. Content type: Research

    Temporal lobe epilepsy (TLE) is the most common form of partial epilepsy and is accompanied, in one third of cases, by resistance to antiepileptic drugs (AED). Most AED target neuronal activity modulated by io...

    Authors: Adriana Fernanda K. Vizuete, Fernanda Hansen, Elisa Negri, Marina Concli Leite, Diogo Losch de Oliveira and Carlos-Alberto Gonçalves

    Citation: Journal of Neuroinflammation 2018 15:68

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  21. Content type: Correction

    After publication of the article [1], it was brought to our attention that an acknowledgement was missing from the original version.

    Authors: Shinji Yamamoto, Kota Yamashina, Masaki Ishikawa, Mari Gotoh, Sosuke Yagishita, Kensuke Iwasa, Kei Maruyama, Kimiko Murakami-Murofushi and Keisuke Yoshikawa

    Citation: Journal of Neuroinflammation 2018 15:67

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    The original article was published in Journal of Neuroinflammation 2017 14:142

  22. Content type: Research

    Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects the motor neuromuscular system leading to complete paralysis and premature death. The multifactorial nature of ALS th...

    Authors: Antonio Vallarola, Francesca Sironi, Massimo Tortarolo, Noemi Gatto, Roberta De Gioia, Laura Pasetto, Massimiliano De Paola, Alessandro Mariani, Supurna Ghosh, Richard Watson, Andreas Kalmes, Valentina Bonetto and Caterina Bendotti

    Citation: Journal of Neuroinflammation 2018 15:65

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  23. Content type: Research

    Multiple sclerosis (MS) is characterized by a combination of inflammatory and neurodegenerative processes variously dominant in different stages of the disease. Thus, immunosuppression is the goal standard for...

    Authors: Carmen Navarrete, Francisco Carrillo-Salinas, Belén Palomares, Miriam Mecha, Carla Jiménez-Jiménez, Leyre Mestre, Ana Feliú, Maria L. Bellido, Bernd L. Fiebich, Giovanni Appendino, Marco A. Calzado, Carmen Guaza and Eduardo Muñoz

    Citation: Journal of Neuroinflammation 2018 15:64

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  24. Content type: Research

    Angiotensin II (Ang II), a peptide hormone involved in the development of hypertension, causes systemic and cerebral inflammation, affecting brain regions important for blood pressure control. The cause-and-ef...

    Authors: M. Florencia Iulita, Diane Vallerand, Mélissa Beauvillier, Nathalie Haupert, Corinne A. Ulysse, Audrey Gagné, Nathalie Vernoux, Sonia Duchemin, Michaël Boily, Marie-Ève Tremblay and Hélène Girouard

    Citation: Journal of Neuroinflammation 2018 15:62

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  25. Content type: Research

    Low-grade inflammation has been repeatedly associated with both excess weight and psychosis. However, no previous studies have addressed the direct effect of body mass index (BMI) on basal serum cytokines in i...

    Authors: María Juncal-Ruiz, Laura Riesco-Dávila, Víctor Ortiz-García de la Foz, Mariluz Ramírez-Bonilla, Obdulia Martínez-García, Juan Irure-Ventura, Juan Carlos Leza, Marcos López-Hoyos and Benedicto Crespo-Facorro

    Citation: Journal of Neuroinflammation 2018 15:63

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