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Archived Comments for: β-Amyloid promotes accumulation of lipid peroxides by inhibiting CD36-mediated clearance of oxidized lipoproteins

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  1. Oxidative - Redox stress by Beta amyloid may also be true for islet amyloid within pancreatic islets of those patients with metabolic syndrome and type 2 diabetes mellitus.

    Melvin Hayden, University of Missouri School of Medicine Department of Family and Community Medicine

    16 November 2004

    Congratulations on an excellent study and the important findings regarding the effect of beta amyloid on lipoprotein oxidation.

    We feel the same effect of islet amyloid might be occuring within the islets of the pancreata of patients with metabolic syndrome and type 2 diabetes mellitus. Islet amyloid and beta amyloid share many similar properties (including the polymerization and aggregation induced by free radical polymerization) and it is exciting that the translation of your findings to the islet in regards to hyperamylinemia and islet amyloid within the pancreas may possibly explain the delay in the development of overt type 2 diabetes mellitus with the use of pravastatin in the West of Scotland studies.

    Hayden MR, Tyagi SC. Islet Redox Stress: The Manifold Toxicities of Insulin Resistance, Metabolic Syndrome and Amylin Derived Islet Amyloid in Type 2 Diabetes Mellitus. JOP. J Pancreas (Online) 2002; 3(4):86-108

    Nicolls MR, D'Antonio JM, Hutton JC, Gill RG, Czwornog JL, Duncan MW. Proteomics as a tool for discovery: proteins implicated in Alzheimer's disease are highly expressed in normal pancreatic islets. J Proteome Res 2003; 2(2):199-205

    Keep up the exciting work in this field and again kudos for this great and exciting paper.


    M.R. Hayden, M.D.

    Competing interests