Table 1 Ginkgolide-treated SH-SY5Y cells are resistant to PrP peptides/amyloid-β1-42: The survival of SHSY-5Y cells in control medium, medium containing 1 μM ginkgolides A, 1 μM ginkgolide B, 25 μM myricetin or 25 μM quercetin for 3 hours and subsequently incubated for 24 hours with 5 μM sPrP106, 10 μM HuPrP82-146 or 10 μM amyloid-β1-42. Values shown represent the percentage survival of cells compared to untreated cells. Each value is the mean ± SD from triplicate experiments repeated four times (12 observations).
From: Ginkgolide B inhibits the neurotoxicity of prions or amyloid-β1-42
untreated | sPrP106 | HuPrP82-146 | amyloid-β1-42 | |
|---|---|---|---|---|
control medium | 100 ± 3 | 69 ± 4 | 64 ± 6 | 48 ± 10 |
ginkgolide A | 101 ± 5 | 99 ± 3** | 101 ± 2** | 99 ± 4** |
ginkgolide B | 99 ± 3 | 99 ± 5** | 98 ± 3** | 96 ± 3** |
myricetin | 101 ± 7 | 67 ± 3 | 65 ± 3 | 46 ± 5 |
quercetin | 100 ± 4 | 66 ± 4 | 66 ± 5 | 44 ± 5 |