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Table 1 Ginkgolide-treated SH-SY5Y cells are resistant to PrP peptides/amyloid-β1-42: The survival of SHSY-5Y cells in control medium, medium containing 1 μM ginkgolides A, 1 μM ginkgolide B, 25 μM myricetin or 25 μM quercetin for 3 hours and subsequently incubated for 24 hours with 5 μM sPrP106, 10 μM HuPrP82-146 or 10 μM amyloid-β1-42. Values shown represent the percentage survival of cells compared to untreated cells. Each value is the mean ± SD from triplicate experiments repeated four times (12 observations).

From: Ginkgolide B inhibits the neurotoxicity of prions or amyloid-β1-42

  untreated sPrP106 HuPrP82-146 amyloid-β1-42
control medium 100 ± 3 69 ± 4 64 ± 6 48 ± 10
ginkgolide A 101 ± 5 99 ± 3** 101 ± 2** 99 ± 4**
ginkgolide B 99 ± 3 99 ± 5** 98 ± 3** 96 ± 3**
myricetin 101 ± 7 67 ± 3 65 ± 3 46 ± 5
quercetin 100 ± 4 66 ± 4 66 ± 5 44 ± 5
  1. ** = Cell survival significantly greater (p < 0.05) than cells incubated with peptides in the absence of drugs.