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Figure 1 | Journal of Neuroinflammation

Figure 1

From: Western-type diet modulates inflammatory responses and impairs functional outcome following permanent middle cerebral artery occlusion in aged mice expressing the human apolipoprotein E4 allele

Figure 1

High-fat diet increases total serum cholesterol in aged ApoE3-TR and ApoE4-TR mice to similar levels. Serum cholesterol levels were measured 10 days post stroke. ApoE3-TR and ApoE4-TR mice on a high-fat (HF) diet showed similar cholesterol levels. ApoE, apolipoprotein E; E3, E4 and WT, ApoE3-TR, ApoE4-TR and control mice; ND, normal diet; Sham and Isch, sham-operated and ischemic mice; TR, targeted replacement. Data expressed as mean ± standard error of the mean. WTND + sham, n = 7; WTND + Isch, n = 15; WTHF + Isch, n = 7; E3ND + sham, n = 5; E3ND + Isch, n = 7; E3HF + Isch, n = 8; E4ND + sham, n = 10; E4ND + Isch, n = 9; E4HF + Isch, n = 5. * p < 0.05, ** p < 0.01 and *** p < 0.001.

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Journal of Neuroinflammation

ISSN: 1742-2094