Skip to main content
Figure 2 | Journal of Neuroinflammation

Figure 2

From: Western-type diet modulates inflammatory responses and impairs functional outcome following permanent middle cerebral artery occlusion in aged mice expressing the human apolipoprotein E4 allele

Figure 2

Effect of apolipoprotein E isoforms alone or combined with a western diet on infarct size. A long-term high-fat (HF) diet results in clear sensorimotor deficits in ApoE4-TR mice 3 days after permanent middle cerebral artery occlusion without effect on the lesion size. (A) Infarct lesions were quantified from magnetic resonance images taken 72 hours post ischemia for WTND (n = 15), WTHF (n = 8), E3ND (n = 8), E3HF (n = 9), E4ND (n = 9) and E4HF (n = 8). Sensorimotor deficits were assessed using an adhesive removal test at (B) 3 days and (C) 7 days post ischemia. ApoE, apolipoprotein E; E3, E4 and WT, ApoE3-TR, ApoE4-TR and control mice; ND, normal diet; Sham and Isch, sham-operated and ischemic mice; TR, targeted replacement; WT, wild type. Data expressed as mean ± standard error of the mean. WTND + Sham, n = 8; WTND + Isch, n = 15; WTHF + Isch, n = 10; E3ND + Sham, n = 6; E3ND + Isch, n = 8; E3HF + Isch, n = 9; E4ND + Sham, n = 10; E4ND + Isch, n = 13; E4HF + Isch, n = 8. * p < 0.05, ** p < 0.01 and *** p < 0.001.

Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094