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Figure 1 | Journal of Neuroinflammation

Figure 1

From: In an in vitro model of human tuberculosis, monocyte-microglial networks regulate matrix metalloproteinase-1 and -3 gene expression and secretion via a p38 mitogen activated protein kinase-dependent pathway

Figure 1

Matix metalloproteinsase (MMP)-1 and MMP-3 secretion is up-regulated by conditioned media from tuberculosis (TB)-infected monocytes (CoMTb) in a dose- and time-dependent fashion. (A and B) Microglial cells were stimulated with control medium (open bars), or increasing concentrations of conditioned media from control monocytes (CoMCont) (diagonal hatched bars) and CoMTb (solid bars); 72-hour supernatants were analyzed by Luminex for MMP-1 or MMP-3. A representative casein zymogram is also shown (A). Kinetics of MMP-1 activity (C) and MMP-3 secretion (D) demonstrate progressive increase in concentration for up to 72 hours. Bars represent mean values ± SD of three samples, representative of at least duplicate experiments performed in triplicate. * P <0.05, ** P <0.01.

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Journal of Neuroinflammation

ISSN: 1742-2094