Protective effect of IL-1 receptor antagonist (IL-1ra) on lipopolysaccharide (LPS) + hypoxia-ischemia (HI)-induced brain lesions. (A) Magnetic resonance imaging of LPS + HI-exposed rat brains ± treatment with IL-1ra. Arrowheads show the areas of damage. No visible damage was observed in the left hemisphere. (B) Mean ± standard error of the mean lesion volume after LPS + HI exposition ± treatment with IL-1ra. (C) Three-dimensional reconstruction of the lesion after LPS + HI ± IL-1ra (5 to 6 rats per condition). Unpaired t-test with Welch correction; **
P ≤ 0.01. R right side, mm
3 cubic millimeters.