Figure 1

Analysis of interleukin (IL)-1β gene expression in the hippocampus of SERT mutant rats. Basal expression of IL-1β mRNA levels were measured in dorsal (A) and ventral (B) hippocampus of mutant rats. The data, expressed as percentage of SERT^+/+ (wild-type) animals (set at 100%), are the mean ± SEM of at least five independent determinations. *P < 0.05, **P < 0.01 and ***P < 0.001 vs. SERT^+/+ (one-way ANOVA with SCPHT). The expression of IL-1β was also investigated in dorsal (C) and ventral (D) hippocampus following an acute LPS challenge, the animals being killed 1 or 5 days after the immune challenge. The data are expressed as percentage of the respective saline-injected counterpart (set at 100%, dashed line) and represent the mean ± SEM of at least five independent determinations. #P < 0.05, ##P < 0.01, ###P < 0.001 vs. control (one-way ANOVA with SCPHT).