Figure 3
From: Altered inflammatory responsiveness in serotonin transporter mutant rats
Analysis of integrin alpha M (CD11b) gene expression in the hippocampus of SERT mutant rats. Basal CD11b gene expression is altered in dorsal (A) and ventral (B) hippocampus of mutant rats. The data, expressed as percentage of SERT+/+ animals (set at 100%), are the mean ± SEM of at least five independent determinations. *P < 0.05, **P < 0.01 and ***P < 0.001 vs. SERT+/+ (one-way ANOVA with SCPHT). The expression of CD11b is upregulated in dorsal (C) and ventral (D) hippocampus of WT or SERT+/− animals 1 or 5 days after an LPS challenge. The data are expressed as percentage of the respective saline-injected counterpart (set at 100%, dashed line) and represent the mean ± SEM of at least five independent determinations. ##P < 0.01, ###P < 0.001 vs. control (one-way ANOVA with SCPHT).