Table 1 Different stages defined in amyotrophic lateral sclerosis
Stage | Age | Phenotype |
|---|---|---|
Pre-symptomatic | 30 days postnatal | No signs of motor deficit |
Onset | 70 days postnatal | Initial signs of motor deficit (grip strength) |
Mid-symptomatic | 130 days postnatal | Weakness in hind-limb and tremor when suspended by the tail |
End | 150 to 175 days postnatal | Full paralysis of lower limbs and loss of righting reflex |