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Table 1 Different stages defined in amyotrophic lateral sclerosis

From: Dysregulation of the complement cascade in the hSOD1G93Atransgenic mouse model of amyotrophic lateral sclerosis

Stage Age Phenotype
Pre-symptomatic 30 days postnatal No signs of motor deficit
Onset 70 days postnatal Initial signs of motor deficit (grip strength)
Mid-symptomatic 130 days postnatal Weakness in hind-limb and tremor when suspended by the tail
End 150 to 175 days postnatal Full paralysis of lower limbs and loss of righting reflex