Skip to main content
Figure 6 | Journal of Neuroinflammation

Figure 6

From: Inflammatory demyelination induces glia alterations and ganglion cell loss in the retina of an experimental autoimmune encephalomyelitis model

Figure 6

Apoptosis in retina crosssections. (A) Immunohistochemical staining of CO and EAE retinas with caspase 3+ (apoptosis protein, red) and DAPI (nuclei, blue) 23 days post immunization. In the merged image more caspase 3+ cells (arrows) are visible in the GCL of EAE animals. (B) Mean cell count of caspase 3+ cells in the GCL of the retinas of CO and EAE animals at 23 days (n = 5 to 7 eyes/group). More caspase 3+ cells were noted in the retinas of EAE animals (CO: 35.0 ± 1.9 cells/mm, EAE: 42.2 ± 2.6 cells/mm, P = 0.0222). Scale bar: 25 μm. *: p<0.05. CO, control; EAE, experimental autoimmune encephalomyelitis; GCL, ganglion cell layer; INL, inner nuclear layer; IPL, inner plexiform layer.

Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094