Figure 2

Neuropathology in the spinal cords of EAE in urokinase plasminogen activator (uPA ^−/− ), or the urokinase plasminogen activator receptor (uPAR ^−/− ) mice compared with WT mice. The results are presented as mean ± standard error (SE) (infiltrates/mm²). (A) uPA^−/− animals exhibited an almost twofold greater inflammatory burden (**P<0.001). (a1,a2) Representative photographs (hematoxylin plus Bielschowsky stain) Magnification x200. (B) uPAR^−/− animals exhibited significantly greater inflammation (*P<0.05). (b1,b2) Representative photographs, magnification x200.