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Figure 6 | Journal of Neuroinflammation

Figure 6

From: Optical tomographic imaging of near infrared imaging agents quantifies disease severity and immunomodulation of experimental autoimmune encephalomyelitis in vivo

Figure 6

NIR tomographic multiplex imaging AS750 and CB680 in control and PLP-tolerized mice. (A) Tomographic images of vascular leak and cathepsin B activity in brain and lumbar/sacral spinal cord of control OVA-tolerized mice (left panel). Extraneous non-CNS signal was excluded for clarity. Right panel shows CB680/AS750 signal from excised brain and spinal cord tissue. (B) Tomographic images of vascular leak and cathepsin B activity in brain and lumbar/sacral spinal cord of control PLP-tolerized mice (left panel). Extraneous non-CNS signal was excluded for clarity. Right panel shows CB680/AS750 signal from excised brain and spinal cord tissue. Tomographic images from A and B are represented as fluorescence isosurfaces showing signal ≥65 nM (CB680 brain), ≥200 nM (AS7750 brain) and ≥100 nM (CB680/AS750 spine). Epifluorescence images are represented with the same monochrome color scales for both control and tolerized mouse tissues.

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Journal of Neuroinflammation

ISSN: 1742-2094