PLP-ISEdel mice show motor impairments in the open field task. Mice were placed in an open field maze for 30 minutes and their activity was recorded and analyzed using video tracking software. A significant impairment was found in total distanced traveled (A), and velocity of movement (B). In the 4-month-old group, an age-related difference in thigmotaxis behavior between the wild-type (WT) and PLP-ISEdel mice was found (C), which is shown in a computer-generated trace of the animal’s movements over 30 minutes (D). (2-month-old WT (n = 15) versus PLP (n = 16); 4-month-old WT (n = 12) versus PLP (n = 12).