Figure 1

Plasma antibody levels to aggregated Aβ40, Aβ42 and pBri in pBri-vaccinated mice. Shown are bar graphs of the IgM and IgG antibody levels of (A) TgSwDI and (B) 3xTg and against Aβ40, Aβ42 and pBri at T0 (before vaccination), T1 (after the fourth inoculation) and Tf (at the time of sacrifice). Plasma samples were evaluated at a dilution of 1:100 in duplicate. (*P ≤ 0.05, **P ≤ 0.01 and ***P ≤ 0.001 by unpaired two-tailed t-tests, comparing values at T1 and Tf to T0. Error bars represent mean ± standard error of the mean). Aβ, amyloid β; OD, optical density.