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Table 1 Clinical features of RE patients

From: Inflammasome induction in Rasmussen’s encephalitis: cortical and associated white matter pathogenesis

  Patient 1 Patient 2 Patient 3 Patient 4
Age of onset, gender 3 years, female 8 years, female 14 years, male 12 years, female
Seizure type CPS, Gen, right face/hand EPC CPS, right face/hand EPC CPS, right face/hand EPC CPS, right face/hand EPC
Hemisphere Left Left Bilateral Left
Neurologic deficit(s) Right hemiparesis Right hemiparesis Right hemiparesis, aphasia Right hemiparesis
Neuroimaging Cortical and white matter signal Cortical and white matter signal Cortical and white matter signal Cortical and white matter signal
Surgery, age Left hemispherectomy, 4 years Left hemispherectomy, 11 years SPT, 17 years; left face/hand area resection, 17 years Left face/hand area resection, 18 years
Neuropathology Mononuclear cell infiltration with gliosis Mononuclear cell infiltration with gliosis Mononuclear cell infiltration with gliosis Mononuclear cell infiltration with gliosis
Clinical outcome Engel class I, seizure-free (at 14 months) Engel class I, seizure-free (at 24 months) Engel class IV, death Engel class III, 2 years (lost to follow-up)
Treatment(s) GCs, no benefit GCs, good response GCs, IVIg, tacrolimus, cyclophosphamide (50 mg/kg) GCs, IVIg, methotrexate, no benefit
  1. CPS, complex partial seizure; EPC, epilepsia partialis continua; GCs, glucocorticoids; Gen, generalized seizures; IVIg, intravenous immune globulin; RE, Rasmussen’s encephalitis; SPT, subpial transaction.