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Figure 1 | Journal of Neuroinflammation

Figure 1

From: Erythropoietin improves motor and cognitive deficit, axonal pathology, and neuroinflammation in a combined model of diffuse traumatic brain injury and hypoxia, in association with upregulation of the erythropoietin receptor

Figure 1

Erythropoietin (EPO) promotes significant improvement in motor function in rats subjected to traumatic axonal injury with hypoxia (TAI + Hx), but not in traumatic axonal injury (TAI) alone. Rats were trained on the Rotarod task for 7 d prior to injury, then tested daily for 6 d after surgery and on every second day until 14 d. (A) The deficit observed after TAI and TAI + EPO rats was similar 1 d postinjury. TAI rats made a steady recovery and improved throughout the course of the 2-week testing period; however there was no additional improvement after EPO treatment. (B) Both TAI + Hx and TAI + Hx + EPO groups achieved identical rpm scores on the Rotarod until 4 d postinjury, from which point TAI + Hx + EPO rats were performing significantly better on the Rotarod by 6 d than TAI + Hx rats. By 10 d, TAI + Hx + EPO rats reached an rpm similar to sham, with this beneficial effect maintained out to the end of the testing period. Data shown as mean ± SEM. N at 1 day = 24/group; 2 to 6 days = 12/group; 8 to 14 days = 6/group. Data was analysed by 2-way ANOVA repeated measures with Bonferroni post hoc test, with a P value of <0.05 considered significant.

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Journal of Neuroinflammation

ISSN: 1742-2094