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Figure 1 | Journal of Neuroinflammation

Figure 1

From: Interleukin-10 modulates the synthesis of inflammatory mediators in the sensory circumventricular organs: implications for the regulation of fever and sickness behaviors

Figure 1

TNF-α and IL-6 concentrations in supernatants of OVLT microcultures. The microcultures were treated with IL-10AB or PBS 30 minutes before LPS or PBS. The supernatants of the OVLT microcultures were collected 6 h after treatment with LPS (final concentration: 100 μg/ml) or PBS, and concentrations of TNF-α (A) and IL-6 (B) were determined by specific bioassays. Columns represent means with SD (n = 11–23). * Significant differences between microcultures treated with LPS + PBS vs LPS + IL-10AB. # Significant differences between microcultures treated with PBS + IL-10AB vs LPS + PBS and LPS + IL-10AB. + Significant differences between microcultures receiving no treatment vs LPS + PBS and LPS + IL-10AB. No significant differences were noted between microcultures receiving no treatment and microcultures treated with PBS + IL-10AB.

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