C5L2 antibodies label dystrophic neurites associated with plaques as well as neurofibrillary tangles. Representative pictures of C5L2 staining using antibody N1-50 in FC of VD (A) and hippocampus of control (B) and VD (C) brain, and FC (D) or hippocampus of two AD cases (E, F). Arrowhead in D shows dystrophic neurites associated with plaques in cortex (DNP). Insert in E shows DNP in hippocampus. Scale bars: 50 um. AD, Alzheimer’s disease; FC, frontal cortex; VD, vascular dementia.