Figure 7From: Treatment with an anti-CD11d integrin antibody reduces neuroinflammation and improves outcome in a rat model of repeated concussion White matter injury measured by the increase in amyloid precursor protein (APP) expression in the brain after repeated mild fluid percussion injury is reduced by the anti-CD11d treatment. (A) Photomicrographs of brain sections at the center of the corpus callosum, 72 h after injury, immunostained by an antibody to APP. Format is as in Figure 3. Scale bars = 100 μm. (B) APP, identified by western blotting in brain homogenates, is shown at 72 h and 8 weeks in sham-injured, 1B7, and anti-CD11d groups (n = 6, all groups). A.U., arbitrary units; *different from sham-injured group; #different from 1B7 group; all P ≤0.05.Back to article page