White matter injury measured by the increase in amyloid precursor protein (APP) expression in the brain after repeated mild fluid percussion injury is reduced by the anti-CD11d treatment. (A) Photomicrographs of brain sections at the center of the corpus callosum, 72 h after injury, immunostained by an antibody to APP. Format is as in Figure 3. Scale bars = 100 μm. (B) APP, identified by western blotting in brain homogenates, is shown at 72 h and 8 weeks in sham-injured, 1B7, and anti-CD11d groups (n = 6, all groups). A.U., arbitrary units; *different from sham-injured group; #different from 1B7 group; all P ≤0.05.