Figure 4

Effect of RA on neurological damage 24 h and 14 days in diabetic cerebral ischemia-reperfusion ( I / R ) rats. A: Effect of RA on cerebral pathological damage after cerebral I/R in diabetic rats. Sections were stained with NeuN after fixation. A1: diabetic group; A2: Vehicle-treated group (24 h); A3: RA 50 mg/kg group; A4: Vehicle-treated group (14th day); A5: RA, 50 mg/kg, group (14th day). B: Effect of RA on the NeuN-immunopositive neurons after cerebral I/R in diabetic rats. RA indicates rosmarinic acid. Results were averaged and expressed as the number of NeuN-immunopositive neurons per section. Data are means ± SD, n = 5. ^* P <0.01 vs Vehicle-treated group. Significance was determined by one-way ANOVA followed by Dunnett’s test.