Figure 8From: Lack of transient receptor potential vanilloid 1 channel modulates the development of neurogenic bladder dysfunction induced by cross-sensitization in afferent pathways Differences in visceral sensitivity between WT and TRPV1 KO mice in response to mechanical stimulation of the lower abdominal region. (A) Abdominal responses to Von Frey filaments in wild-type (WT) mice with vehicle instillations (N = 4). (B) Responses to pelvic stimulation in WT mice before and after intracolonic treatment with 2,4,6-trinitrobenzene sulfonic acid (TNBS) (N = 5). (C) Time course of the responses to mechanical stimulation of the lower pelvic area in transient receptor potential vanilloid 1 knockout (TRPV1 KO) mice before and after intracolonic instillations of the vehicle (N = 4). (D) Summary of the responses to pelvic stimulation recorded in TRPV−/− male mice during experimental colitis (N = 6). Presented data are mean percentages of response frequency (± SE) before (baseline) and at days 1, 2, and 3 post-treatment. ANOVA indicated a significant increase in response frequency in WT mice within 3 days post-TNBS treatment, whereas in KO mice the difference reached statistical significance only at days 2 and 3 after the induction of colonic inflammation.Back to article page