Figure 5
From: Macrophages in inflammatory multiple sclerosis lesions have an intermediate activation status
CD40 and mannose receptor (MR) expression on foamy macrophages in an active multiple sclerosis (MS) lesion. Images are taken at the center of an active MS lesion stained for human leukocyte antigen-DR (HLA-DR) (A) and CD40 (B). Colocalization studies showed a clear overlap of HLA-DR and CD40 (C). Double staining with anti-CD40 (D) and -MR (E) shows that 70% of the CD40 positive cells were also MR positive, all MR positive cells are CD40 positive (F).