Figure 3
From: Amelioration of autoimmune neuroinflammation by the fusion molecule Fn14·TRAIL
Treatment with Fn14·TRAIL improves central nervous system (CNS) inflammation and reduces experimental autoimmune encephalomyelitis (EAE) lesions. Spinal cords of mice from control and Fn14·TRAIL groups were removed at disease peak (day 20 post-induction). Hematoxylin-eosin staining revealed marked perivascular, meningeal and white matter infiltration in EAE mice treated with vehicle ((A) 10X magnifications and (B) 40X magnification of one perivascular inflammatory lesion). Following treatment with Fn14·TRAIL 200 μg/day for 7 days, a marked and significant reduction in inflammation was observed (C, D) *P <0.05.