COX-2 inhibitors
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Müller et al. 2006 [238]
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RCT
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Celecoxib (200 mg bid) + reboxetine versus placebo + reboxetine
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40 MDD (acute)
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Significantly greater decrease in depressive symptoms in the treatment group (P = 0.035)
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Akhondzadeh et al. 2009 [239]
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RCT
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Celecoxib (200 mg bid) + fluoxetine versus placebo + fluoxetine
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40 MDD
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Significant improvement of depressive symptoms (P <0.001), and a greater percentage of responders (90% versus 50%, P = 0.01) and remission (35% versus 5%, P = 0.04) in the treatment group
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Medlewicz et al. 2006 [240]
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Open-label
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Acetylsalicylic acid (160 mg qd) + SRI
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24 MDD and BPD
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52.4% responder rate, significant improvement within one week (P <0.0001) following treatment; sustained at four weeks
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ClinicalTrials.gov http://www.clinicaltrials.gov/NCT00510822 completed, pending results
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RCT
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Cimicoxib (50 mg bid) + sertraline versus placebo + sertraline
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169 MDD
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Primary outcome measure is mean change in Hamilton Depression Rating Scale from baselineto six-week endpoint
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Nery et al. 2008 [263]
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RCT
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Celecoxib versus placebo
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28 BPD (depressive and mixed states)
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No significant differences in depressive or manic symptoms.
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Müller et al. 2002 [242]
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RCT
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Celecoxib (400 mg qd) + risperidone versus placebo + risperidone
|
50 (acute schizophrenia)
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Significant improvement of positive and negative symptoms (P = 0.05), as well as cognition (P <0.06) in treatment group at five weeks
|
Müller et al. 2010 [244]
|
RCT
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Celecoxib + amisulpride versus placebo + amisulpride
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49 schizophrenia (first-episode)
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Significant improvement of positive and negative symptoms in celecoxib plus amisulpride group relative to amisulpride alone (P <0.001) at six-weeks
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Sayyah et al. 2011 [245]
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RCT
|
Celecoxib (200 mg bid) + fluoxetine versus placebo + fluoxetine
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50 OCD
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Significantly greater reduction in YBOCS scores in the celecoxib treatment group at two weeks (P = 0.007) and at the eight week end-point (P = 0.037)
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Minocycline
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Levine et al. 1996 [264]
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Case report
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Minocycline (150 mg qd) started 20 years after disease onset
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1 BPD
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Marked decrease in depressive symptoms (HAM-D score went from 25 to 8) within one week following treatment, sustained at two weeks.
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Levkovitz et al. 2009 [265]
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RCT
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Minocycline (200 mg qd) versus placebo
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21 schizophrenia (early and acute-phase)
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Significant improvement of negative symptoms and cognitive dysfunction in treatment group (P <0.01)
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ClinicalTrials.gov NCT01433055 recruiting, estimated completion 7/15
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RCT
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Minocycline (100 mg bid) + clozapine versus placebo + clozapine
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60 schizophrenia (refractory to ≥2 antipsychotics)
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Primary outcome is the improvement in positive symptoms as measured by the four-item sub-factor of the Brief Psychiatric Rating Scale.
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Miyaoka et al. 2007 [266]
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Case series
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Minocycline (150 mg qd) + stable antipsychotic regiment
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2 schizophrenia
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Complete resolution of positive and negative symptoms with minocycline, sustained for one to two years. Symptom exacerbation occurred one-week following minocycline discontinuation (in both cases). In one patient, the complete resolution of symptoms occurred at age 61, which was 41 years after disease onset.
|
Miyaoka et al. 2008 [267]
|
Open-label
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Minocycline (150 mg tid)
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22 schizophrenia
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Significant improvement of positive and negative symptoms at four to eight weeks (P = 0.0001)
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Rodriguez et al. 2010 [268]
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Open-label
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Minocycline (100 mg bid)
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9 OCD
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22% had a 40% to 46% YBOCS reduction at 12 weeks; the group as a whole did not have a significant change in YBOCS score.
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