Figure 3

Absence of motor deficits in DJ-1−/− mice exposed to prolonged, serial low-dose systemic lipopolysaccharide. No significant differences were detected between genotypes or treatment groups in (A) the time to walk across a narrow beam or (B) the time before falling off an accelerating rotarod, suggesting no general malaise or overt motor deficits compared to wild-type saline-treated mice. Bars represent mean ± SEM; n = 8 per group. Analysis by three-way analysis of variance followed by a Tukey’s HSD post hoc test at P < 0.05 for significance. For rotarod: genotype F_{(1, 232)} = 3.46, P = 0.064; treatment F_{(1, 232)} = 0.76, P = 0.383. For beam walk: genotype F_{(1, 232)} = 1.86, P = 0.173; treatment F_{(1, 232)} = 2,92, P = 0.089. LPS, lipopolysaccharide; mo, months.