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Table 1 Sickness response measures following ICV LPS

From: Interleukin-1 beta converting enzyme is necessary for development of depression-like behavior following intracerebroventricular administration of lipopolysaccharide to mice

  Δ Body weight (g / 24 h) Line crossings (# / 5 min) Rearings (# / 5 min)
WT −0.10 ± 0.12a 62.7 ± 5.5a 50.3 ± 5.0a
WT-LPS −1.83 ± 0.39b 63.3 ± 6.5a 47.9 ± 5.0a
ICE KO 0.17 ± 0.13a 30.0 ± 2.6b 25.7 ± 1.9b
ICE KO-LPS −1.64 ± 0.12b 35.5 ± 6.4b 28.5 ± 5.2b
  1. Body weight was measured at 0 and 24 h and body weight change was calculated from these measures; locomotor activity was tested 24 h after treatment. Averages within columns with different superscript letters are significantly different; P <0.05.