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Table 1 Sickness response measures following ICV LPS

From: Interleukin-1 beta converting enzyme is necessary for development of depression-like behavior following intracerebroventricular administration of lipopolysaccharide to mice

 

Δ Body weight (g / 24 h)

Line crossings (# / 5 min)

Rearings (# / 5 min)

WT

−0.10 ± 0.12a

62.7 ± 5.5a

50.3 ± 5.0a

WT-LPS

−1.83 ± 0.39b

63.3 ± 6.5a

47.9 ± 5.0a

ICE KO

0.17 ± 0.13a

30.0 ± 2.6b

25.7 ± 1.9b

ICE KO-LPS

−1.64 ± 0.12b

35.5 ± 6.4b

28.5 ± 5.2b

  1. Body weight was measured at 0 and 24 h and body weight change was calculated from these measures; locomotor activity was tested 24 h after treatment. Averages within columns with different superscript letters are significantly different; P <0.05.
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Journal of Neuroinflammation

ISSN: 1742-2094