Figure 3
From: Neurogenic factor-induced Langerhans cell activation in diabetic mice with mechanical allodynia
CD207-positive LCs express Trk A immunoreactivity. Representative images of Trk A/CD207 double immunohistochemistry of hind foot pads from db/+ (A,B,C) and db/db (D,E,F) mice at 8 weeks of age. Trk A immunoreactivity was detected in both IENFs (A,D, arrows) and nerve fibers in the subepidermal nerve plexus (A,D, asterisks) in both db/+ and db/db mice. In addition, CD207-positive LCs were positive for Trk A (B,C,E,F, arrowheads). Most CD207-positive cells also expressed Trk A immunoreactivity in both db/+ (B, arrowheads) and db/db mice (E, arrowheads). Bar = 50 μm, n = 8. Epi, epidermis; IENF, intraepidermal nerve fiber; LC, Langerhans cell; Trk, tropomyosin-receptor kinase.