Figure 5
From: Neurogenic factor-induced Langerhans cell activation in diabetic mice with mechanical allodynia
Subepidermal CD68-positive cells of db/db mice are positive for RAGE. Representative images of CD68/RAGE double immunohistochemistry of hind foot pads from db/+ (A,B,C) and db/db (D,E,F) mice at 8 weeks of age. RAGE immunoreactivity was only detected in db/db mice (E, arrowheads) but not db/+ mice (B). Most RAGE-positive cells are positive for CD68 (E, arrowheads) with some exceptions (E, arrow). Bar = 50 μm, n = 8. Epi = epidermis; RAGE, receptor for advanced glycation end products.