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Figure 7 | Journal of Neuroinflammation

Figure 7

From: Innate immunity in the Grid2Lc/+ mouse model of cerebellar neurodegeneration: glial CD95/CD95L plays a non-apoptotic role in persistent neuron loss-associated inflammatory reactions in the cerebellum

Figure 7

CD95L and IL-6 levels in the cerebellum of Grid2 Lc/+ . (A) Representative experiment from the CD95L study. CD95L concentrations were determined in crude cerebellum extracts from Grid2Lc/+(open bars) and wild-type (black bars) mice, by ELISA. (B) Representative time-course study of IL-6 levels in the cerebellum of Grid2Lc/+(open diamonds) and wild-type (black diamonds) mice. Levels were determined in a biological activity assay. Note that IL-6 levels begin to increase at the end of the period of massive neuron degeneration (shaded in gray; see Figure 4). The mean values for four determinations are shown, with range error bars.

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Journal of Neuroinflammation

ISSN: 1742-2094