Figure 2

Immunofluorescent micrographs of cerebral extravasations of plasma IgG and apolipoprotein B lipoproteins. The integrity of the BBB was assessed by the detection of brain parenchymal extravasation of plasma derived IgG, and apoB lipoproteins in mice maintained on low-fat control chow (LF), diet enriched in saturated fat (SFA) or each diet supplemented with nutraceutical garlic extract-aged (+GEA), alpha-lipoic acid (+ALA), niacin (+Niacin), or nicotinamide (+NA). (A) The representative images of cerebral extravasation of IgG or apoB in the cortex are shown in green or red, respectively. Nuclei are shown in blue. Scale bar indicates 100 μm. (B) The magnified images of the regions of interest are indicated by a white rectangle in frame A. Vascular endothelial cells are shown with white arrowheads. Scale bar indicates 12 μm.