Figure 1
From: Impaired toll-like receptor 8 signaling in multiple sclerosis
PBMC cytokine gene expression levels after TLR stimulation. (A) IL-12B transcripts were decreased in patients with MS as compared to healthy donors after Toll-like receptor (TLR) 8 stimulation (Student’s unpaired two-tailed t-test, * = P <0.05, n = 10 per group) but not after TLR 3, TLR 7 or TLR 9 stimulation. (B) There was no difference between patients with MS and healthy donors in IFN-alpha transcript production after TLR stimulation. (C) TNF-alpha transcripts were decreased in patients with MS as compared to healthy donors after TLR 3 stimulation (Student’s unpaired two-tailed t-test, * = P <0.05, n = 10 per group) but not after TLR 7, TLR 8 or TLR 9 stimulation. Data shown are median ± 25% to 75% interquartile range relative gene expression of each cytokine normalized to GAPDH and a reference sample. PBMC, peripheral blood mononuclear cells.