Lipopolysaccharide administered via intracerebroventricular injection induced body weight loss and depression-like behavior. (a) Lipopolysaccharide (LPS; 10 ng) decreased body weight over a 24-hour period following treatment. (b) Sucrose preference was decreased by intracerebroventricular LPS. (c) LPS increased tail suspension test (TST) immobility. Data are the average ± standard error of the mean. *P <0.05, **P <0.01. n = 7 mice per group.