Figure 1

Allergy induces changes in the brain transcripts as shown by multivariate analysis. Principal compontent analysis (PCA) and Orthogonal to latent structures discriminant analysis (OPLS-DA) were used to analyze the gene expression in allergic mice (n = 8) and control mice (n = 8). In the frontal cortex, the number of allergic mice was seven. PCA score plots in the hippocampus (A) (Q ² = 0.415 and R ² = 0.615) and in the frontal cortex (B) (Q ² = 0.535 and R ² = 0.692) show an overall view of the data. OPLS-DA score plots indicate group separation between allergic and control mice in the hippocampus (C) (Q ² = 0.488 and R ² = 0.906) and in the frontal cortex (D) (Q ² = 0.590 and R ² = 0.961). H = Hippocampus, FC = Frontal cortex, C = Control, A = Allergic.