Change from baseline for CSF IL-6, plasma IL-6, and plasma CRP for 12 participants over 72 hours. (a) CSF IL-6, (b) plasma IL-6, and (c) plasma CRP. Solid symbols and lines represent patients that received IL-1Ra. Open symbols and dashed lines represent patients that received placebo. CSF, cerebrospinal fluid; CRP, C-reactive protein; IL, interleukin; IL-1Ra, interleukin-1 receptor antagonist.