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Table 5 Analysis of baseline-adjusted AUC from 6 to 24 hours for all outcome measures

From: The effect of intravenous interleukin-1 receptor antagonist on inflammatory mediators in cerebrospinal fluid after subarachnoid haemorrhage: a phase II randomised controlled trial

   Placebo IL-1Ra   
Mediator Location Raw Adjusted Raw Adjusted Difference Pvalue
IL-6 CSF 107.3 0.2 111.0 −12.6 12.8 (−2.1 to 27.7) 0.08
  Plasma 37.7 −3.7 49.7 −22.3 18.6 (−0.6 to 37.7) 0.06
IL-8 CSF 114.8 4.8 104.7 −2.3 7.1 (−5.4 to 19.5) 0.23
  Plasma 37.8 6.4 39.8 −0.3 6.7 (−4.9 to 18.3) 0.23
IL-10 CSF 14.6 −6.3 25.0 −8.1 1.8 (−8.6 to 12.2) 0.70
  Plasma 6.7 0.5 9.1 −17.1 17.6 (4.3 to 30.9) 0.01
MCP-1 CSF 139.8 1.5 145.4 −4.0 5.5 (−3.9 to 15.0) 0.22
  Plasma 68.7 −4.3 79.2 −4.0 −0.3 (−14.0 to 13.3) 0.96
CRP Plasma 65.2 −1.6 84.5 −0.5 −1.1 (−10.3 to 8.1) 0.79
  1. Figures are the mean AUC for the natural logarithm of each marker plotted against time from 6 to 24 hours. Both ‘raw’ (actual values) and baseline-adjusted (subtracting the rectangular area defined by the height of the baseline reading across the 18-hour period) are presented. The mean difference (95% CI) and associated P value are given for the adjusted values. AUC, area under the curve; CRP, C-reactive protein; CSF, cerebrospinal fluid; IL, interleukin; IL-1Ra, interleukin-1 receptor antagonist; MCP-1, monocyte chemoattractant protein-1.