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Figure 8 | Journal of Neuroinflammation

Figure 8

From: Hypertonic saline alleviates cerebral edema by inhibiting microglia-derived TNF-α and IL-1β-induced Na-K-Cl Cotransporter up-regulation

Figure 8

The effect of TNF-R and IL-1R antagonists on NKCC1 mRNA and protein expression in astrocytes. Bar graphs A and B show that NKCC1 mRNA expression in astrocytes is significantly down-regulated by TNF-R and IL-1R antagonists (*P < 0.05). Panel C shows NKCC1 (170 kDa) and β-actin (43 kDa) immunoreactive bands, respectively. Bar graph D shows significant reduction in the optical density of NKCC1 protein following TNF-R and IL-1R antagonist treatment (**P < 0.01). IL-1R, interleukin-1 receptor; NKCC1, Na-K-Cl Cotransporter 1; TNF-α, tumor necrosis factor-alpha.

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Journal of Neuroinflammation

ISSN: 1742-2094