Skip to main content
Figure 5 | Journal of Neuroinflammation

Figure 5

From: Neuronal CCL2 is upregulated during hepatic encephalopathy and contributes to microglia activation and neurological decline

Figure 5

INCB or C021 pretreatment reduces G-protein signaling pathway activity and proinflammatory cytokine production. (A) Immunoblots and subsequent analyses for pERK1/2 and tERK1/2 in cortex lysates from mice administered AOM, AOM + INCB, and AOM + C021. (B) IL-1β mRNA expression in the cortex of vehicle-, AOM-, AOM + INCB-, and AOM + C021-treated mice, n = 3. (C) Cortical IL-6 mRNA expression in vehicle-, AOM-, AOM + INCB- and AOM + C021-treated mice, n = 3. For pERK1/2 immunoblotting analyses * P <0.05 compared to AOM-treated mice. For mRNA analyses * P <0.05 compared to vehicle-treated mice.

Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094