Peripheral splenocyte activation is inhibited in the presence of mepazine. Splenocytes from MOG peptide-immunized mice were cultured and stimulated with the indicated concentrations of MOG peptide in the presence or absence of mepazine (n = 4 for each condition). Culture supernatants were collected 48 h after MOG peptide stimulation and assayed for IL-2 (A), IFNγ (B) and IL-17 (C). Results are displayed as mean ± SEM. *P <0.05, **P <0.01, ***P <0.001.