Figure 1

IRF3-deficient mice develop less severe experimental autoimmune encephalomyelitis than wild-type mice. Interferon regulatory factor 3–knockout (IRF3ko, irf3 ^−/−) and wild-type (WT) mice were immunised with myelin oligodendrocyte glycoprotein (MOG_35–55) in complete Freund’s adjuvant, and Bordetella pertussis toxin was administered on day 0 and day 2. (A) Mice were scored daily for clinical signs of experimental autoimmune encephalomyelitis. Data represent average ± SEM of five pooled experiments (see Table 1). Mean maximal (B) and cumulative (C) clinical scores reached in irf3 ^−/− and WT mice in five independent experiments over the full duration of disease are shown.