Figure 6

Prenatal injury significantly impacts motor function in juvenile rats. Digigait analyses at postnatal day 28 demonstrate significant motor impairment and gait abnormalities in both forelimbs and hindlimbs of lipopolysaccharide (LPS; n = 13), transient systemic hypoxia-ischemia (TSHI; n = 14) and TSHI + LPS (n = 21) rats, compared to shams (n = 18). Impairment includes (A) decreased stride length, (B) increased stride variation, (C) decreased time in the propel phase, (D) decreased paw area at peak stride, consistent with toe-walking, and (E) increased stride frequency, which all culminate in (F) increased ataxia coefficients. *P < 0.05, ** P < 0.01, *** P < 0.001, versus shams. CV, Coefficient of variation.