Figure 1

CpG ODN protected neutropenic mice from E. coli meningoencephalitis. (A) Experimental design and impact of CpG ODN pre-treatment (100 μg ip). (B) Survival and (C) clinical score of wt neutropenic mice. Survival of (D) TLR9^-/- neutropenic and (E) immunocompetent wt mice. Meningoencephalitis was induced by injection of 1 × 10⁴ CFU E. coli K1. Kaplan-Meier curves were compared by log-rank test. Differences in clinical scores between CpG- and buffer-treated mice were analyzed by Mann-Whitney U test (**P <0.01; ***P <0.001) and data are shown as median ± 25th/75th percentiles.