Figure 2From: Defense against HSV-1 in a murine model is mediated by iNOS and orchestrated by the activation of TLR2 and TLR9 in trigeminal ganglia TLRs expression in mice brains. Mice were either infected intranasally with 106 p.f.u. of HSV-1 or not infected and they were euthanized 5 days thereafter. The brains were collected, and the RNA was extracted, reverse transcribed in cDNA and real-time PCR for TLR expression indices for C57BL/6 or the indicated knockout (NI) (n = 4) or the respective infected groups (n = 6 to 9) were obtained (*P <0.05; **P <0.01, when comparing the infected animals with the respective non-infected animals); (#P <0.05; ##P <0.01, when comparing the infected C57BL/6 mice with the infected knockout mice). The results shown are representative of two experiments that yielded similar results.Back to article page