Figure 2From: Translocator protein (18 kDa) (TSPO) is expressed in reactive retinal microglia and modulates microglial inflammation and phagocytosis TSPO mRNA and protein expression in reactive microglia. (A) Strong induction of TSPO mRNA levels in isolated microglial cells from MacGreen/Rs1h-/Y mice compared to MacGreen mice. (B) TSPO protein induction in total retinas from MacGreen/Rs1h-/Y mice compared to MacGreen mice. (C) Temporal TSPO mRNA expression profiling shows a high early postnatal expression level and continuous decline to low levels in adult mouse retinas. (D , E) LPS activation of BV-2 microglial cells leads to the induction of TSPO transcripts (D) and protein (E). Data show mean ± SD (n = 3/group, measured in triplicates) **P <0.01 MacGreen/Rs1h-/Y versus MacGreen; ***P <0.001 BV-2 + 50 ng/ml LPS versus BV-2. LPS, lipopolysaccharide; TSPO, translocator protein (18 kDa).Back to article page