Figure 6

The TSPO ligand XBD173 increases microglial phagocytosis. Phagocytosis was monitored in BV-2 cells incubated with latex beads (A, B) or CM-DiI-stained apoptotic 661 W photoreceptor material (C, D). Data show mean ± SEM (n = 9/group) **P <0.01 XBD173 + LPS versus LPS-treated cells, *P <0.05 XBD173 versus vehicle-treated cells. Phagocytosis was monitored in human iPSdM cells incubated with latex beads (E, F) or CM-DiI-stained apoptotic 661 W photoreceptor material (G, H). Data show mean ± SEM (n = 9/group) ***P <0.01 XBD173 + LPS versus LPS-treated cell and XBD173 versus vehicle-treated cells. LPS, lipopolysaccharide; TSPO, translocator protein (18 kDa).