Oxidative stress in the hippocampus is associated with Nox2 expression after sepsis induction. Hippocampi from WT mice were obtained at six hours, twenty-four hours and five days after sepsis onset. (A) Tissue oxidative stress was assessed by measuring 4-hydroxynonenal (4-HNE) levels, expressed as the percent increase over sham. The bottom figure shows one representative Western blot with two bands per experimental condition. (B) Nox2 and (C) Nox4 mRNA expression in the hippocampus after sepsis induction. White bars represent shams and black bars represent sepsis. The statistical significance is expressed as: *P < 0.05 versus sham. n = 5 to 7 in each group. Cyc: cyclophilin B.