Figure 5

Absence of Nox2 prevents glial cell activation in gp91 ^phox-/- mice. Effects of sepsis induction on OX42-like immunoreactivity in CA1 (A), CA3 (B) and DG (C) and GFAP immunoreactivity in CA1 (E), CA3 (F) and DG (G) of gp91^{phox -/-} mice in the hippocampi of animals allowed to survive for five days after sepsis onset. The graphs show optical density data. n = 5 to 6 in each case. (D) Representative digital images of OX42-like immunoreactivity into dentate gyrus (DG) in gp91^phox-/- sham and gp91^phox-/- sepsis mice. (H) Representative digital images of GFAP-like immunoreactivity into DG in gp91^phox-/- sham and gp91^phox-/- sepsis mice.