Figure 5
From: Deoxyglucose prevents neurodegeneration in culture by eliminating microglia
Microglia are killed by deoxyglucose. (A) Glial cultures (containing microglia and astrocytes) from rat cortex were treated ±10 mM deoxyglucose (DOG) for the indicated times, and the density of live and dead (necrotic plus apoptotic) microglia were counted. (B) Pure primary microglia from rat cortex were treated ±10 mM DOG for the indicated times and the density of live and dead (necrotic plus apoptotic) neurons were counted. Data presented as mean ± standard error of the mean for ≥ 3 independent experiments.*Live cells, #dead cells: *, # P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.