mice displayed attenuated brain edema and neuroinflammation post-trauma. (A) TLR4-/- mice displayed decreased brain water content compared with WT mice. ELISA showed a change in the release of IL-1β, IL-6, TNF-α, MCP-1 and RANTES (B, C, D, E, F) in TLR4-/- mice brain tissue 24 hours post-trauma. Values (mean ± SD) are representative of three independent experiments (n = 3 mice/group). *P < 0.05, **P < 0.01.