Figure 5

Curcumin suppressed TLR4/MyD88/NF-κB signaling pathway protein expression in vivo . (A) TLR4 and MyD88 protein expression in the injured tissue was significantly lower in curcumin-treated mice than in vehicle-treated mice at 24 hours post-trauma. (B) NF-κB p65 and p-IκB-α protein expression in the injured tissue was also significantly lower in curcumin-treated mice than in vehicle-treated mice at 24 hours post-trauma. In contrast, IκB-α protein expression was significantly higher in curcumin-treated mice than in vehicle-treated mice post-trauma. Values (mean ± SD) are representative of three independent experiments (n = 3 mice/group). *P < 0.05, **P < 0.01.